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. 2015 May 8;589(11):1257-65.
doi: 10.1016/j.febslet.2015.03.031. Epub 2015 Apr 8.

Mesenchymal-stem-cell-derived exosomes accelerate skeletal muscle regeneration

Yoshihiro Nakamura  1 , Shigeru Miyaki  2 , Hiroyuki Ishitobi  3 , Sho Matsuyama  4 , Tomoyuki Nakasa  4 , Naosuke Kamei  2 , Takayuki Akimoto  5 , Yukihito Higashi  3 , Mitsuo Ochi  4
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Free article

Mesenchymal-stem-cell-derived exosomes accelerate skeletal muscle regeneration

Yoshihiro Nakamura et al. FEBS Lett. .
Free article

Abstract

Mesenchymal stem cell (MSC) transplantation is used for treatment of many diseases. The paracrine role of MSCs in tissue regeneration is attracting particular attention. We investigate the role of MSC exosomes in skeletal muscle regeneration. MSC exosomes promote myogenesis and angiogenesis in vitro, and muscle regeneration in an in vivo model of muscle injury. Although MSC exosomes had low concentrations of muscle-repair-related cytokines, a number of repair-related miRNAs were identified. This study suggests that the MSC-derived exosomes promote muscle regeneration by enhancing myogenesis and angiogenesis, which is at least in part mediated by miRNAs such as miR-494.

Keywords: Exosome; Mesenchymal stem cell; MicroRNA; Regeneration; Skeletal muscle.

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