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Comment
. 2015 Apr 7;21(4):513-4.
doi: 10.1016/j.cmet.2015.03.012.

Inflammasome inhibition: putting out the fire

Mihai G Netea  1 , Leo A B Joosten  2
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Free article
Comment

Inflammasome inhibition: putting out the fire

Mihai G Netea et al. Cell Metab. .
Free article

Abstract

NLRP3-inflammasome activates caspase-1 and processes pro-IL-1β and pro-IL-18 into the active cytokines. Two recent studies describe specific inhibitors of NLRP3 inflammasome that inhibit IL-1β release and inflammation. The specificity and potency of these compounds gives hope that a targeted approach to inhibit NLRP3-driven inflammation may be just around the corner.

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