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Review
. 2015 May;15(5):531-44.
doi: 10.1586/14737140.2015.1023712. Epub 2015 Apr 11.

New insights into the epidemiology of non-Hodgkin lymphoma and implications for therapy

Dai Chihara  1 , Loretta J Nastoupil, Jessica N Williams, Paul Lee, Jean L Koff, Christopher R Flowers
Affiliations
Review

New insights into the epidemiology of non-Hodgkin lymphoma and implications for therapy

Dai Chihara et al. Expert Rev Anticancer Ther. 2015 May.

Abstract

Non-Hodgkin lymphoma (NHL) comprises numerous biologically and clinically heterogeneous subtypes, with limited data examining the risk factors for these distinct disease entities. Many limitations exist when studying lymphoma epidemiology; therefore, until recently, little was known regarding the etiology of NHL subtypes. This review highlights the results of recent pooled analyses examining the risk factors for NHL subtypes. We outline the heterogeneity and commonality among the risk factors for NHL subtypes, with proposed subtype-specific as well as shared etiologic mechanisms. In addition, we describe how the study of lymphoma epidemiology may translate into prevention or therapeutic targeting as we continue to explore the complexities of lifestyle and genetic factors that impact lymphomagenesis.

Keywords: epidemiology; non-Hodgkin lymphoma; risk factors.

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Figures

Figure 1
Figure 1
Schema for a clinical trial evaluating to benefit of vitamin D in conjunction with treatment for nonHodgkin lymphoma
See this image and copyright information in PMC

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