Is there interaction between gut microbial profile and cardiovascular risk in chronic kidney disease patients?

Abstract

Aim: To evaluate the gut microbial profile in chronic kidney disease (CKD) patients and evaluate the possible relationship with inflammation and cardiovascular risk.

Patients & methods: Markers inflammation plasma and bacterial community profile (denaturing gradient gel electrophoresis) were analyzed.

Results: The average number of bands was not different in healthy individuals and CKD patients. The number of bands was negatively associated with plasma levels of VCAM-1 in patients. Flavobacteriaceae bacterium and Listeria monocytogenes were found in patients and Lachnospiraceae bacterium and Butyrivibrio crossotus in healthy individuals.

Conclusion: Although CKD patients did not present altered gut microbial profile, the sequencing of bands suggested a different microbiota between groups. The result suggests a possible relationship between gut microbiota and cardiovascular risk in CKD patients.

Keywords: cardiovascular diseases; chronic renal failure; gut microbiota; inflammation; oxidative stress.