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Review
. 2015:2015:472360.
doi: 10.1155/2015/472360. Epub 2015 Mar 17.

Biomarkers of lung injury in cardiothoracic surgery

Gerwin Erik Engels  1 , Willem van Oeveren  2
Affiliations
Review

Biomarkers of lung injury in cardiothoracic surgery

Gerwin Erik Engels et al. Dis Markers. 2015.

Abstract

Diagnosis of pulmonary dysfunction is currently almost entirely based on a vast series of physiological changes, but comprehensive research is focused on determining biomarkers for early diagnosis of pulmonary dysfunction. Here we discuss the use of biomarkers of lung injury in cardiothoracic surgery and their ability to detect subtle pulmonary dysfunction in the perioperative period. Degranulation products of neutrophils are often used as biomarker since they have detrimental effects on the pulmonary tissue by themselves. However, these substances are not lung specific. Lung epithelium specific proteins offer more specificity and slowly find their way into clinical studies.

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Figures

Figure 1
Figure 1
Schematic representation of an alveolus with its various cell types and their secretion products which may serve as lung injury biomarkers.
See this image and copyright information in PMC

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