Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2015 Jun:103:197-205.
doi: 10.1016/j.fitote.2015.04.007. Epub 2015 Apr 11.

New bioactive flavonoid glycosides isolated from the seeds of Lepidium apetalum Willd

Pingping Shi  1 , Liping Chao  1 , Tingtxing Wang  2 , Erwei Liu  3 , Lifeng Han  3 , Qi Zong  1 , Xiaoxia Li  1 , Yi Zhang  4 , Tao Wang  5
Affiliations

New bioactive flavonoid glycosides isolated from the seeds of Lepidium apetalum Willd

Pingping Shi et al. Fitoterapia. 2015 Jun.

Abstract

Ten flavonoid glycosides, apetalumosides A (1), B1-B7 (2-8), and C (9), quercetin 3-O-(2,6-di-O-β-D-glucopyranosyl)-β-D-glucopyranoside (10), were obtained from the seeds of Lepidium apetalum Willd. Their structures were elucidated by chemical and spectroscopic methods (UV, IR, NMR, and HRESI-TOF-MS). 1-9 were new isolates. The NMR data for 10 was reported here for the first time. On the other hand, activity screening results showed that 1-3 and 10 had triglyceride accumulation inhibitory effects in HepG2 cells. Preliminary structure-activity relationship study revealed that 7-hydroxyl group is an essential moiety.

Keywords: Flavonoid glycosides; HepG2 cells; Lepidium apetalum; Triglyceride accumulation inhibitory effects.

PubMed Disclaimer

Publication types

LinkOut - more resources