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Randomized Controlled Trial
. 2015 Aug 1;16(8):682-9.
doi: 10.1016/j.jamda.2015.03.010. Epub 2015 Apr 11.

Associations Between Ankle-Brachial Index and Cognitive Function: Results From the Lifestyle Interventions and Independence for Elders Trial

Mark A Espeland  1 , Anne B Newman  2 , Kaycee Sink  3 , Thomas M Gill  4 , Abby C King  5 , Michael E Miller  6 , Jack Guralnik  7 , Jeff Katula  8 , Timothy Church  9 , Todd Manini  10 , Kieran F Reid  11 , Mary M McDermott  12 ; LIFE Study Group
Collaborators, Affiliations
Randomized Controlled Trial

Associations Between Ankle-Brachial Index and Cognitive Function: Results From the Lifestyle Interventions and Independence for Elders Trial

Mark A Espeland et al. J Am Med Dir Assoc. .

Abstract

Objective: The objective of this study was to evaluate cross-sectional and longitudinal associations between ankle-brachial index (ABI) and indicators of cognitive function.

Design: Randomized clinical trial (Lifestyle Interventions and Independence for Elders Trial).

Setting: Eight US academic centers.

Participants: A total of 1601 adults ages 70-89 years, sedentary, without dementia, and with functional limitations.

Measurements: Baseline ABI and interviewer- and computer-administered cognitive function assessments were obtained. These assessments were used to compare a physical activity intervention with a health education control. Cognitive function was reassessed 24 months later (interviewer-administered) and 18 or 30 months later (computer-administered) and central adjudication was used to classify individuals as having mild cognitive impairment, probable dementia, or neither.

Results: Lower ABI had a modest independent association with poorer cognitive functioning at baseline (partial r = 0.09; P < .001). Although lower baseline ABI was not associated with overall changes in cognitive function test scores, it was associated with higher odds for 2-year progression to a composite of either mild cognitive impairment or probable dementia (odds ratio 2.60 per unit lower ABI; 95% confidence interval 1.06-6.37). Across 2 years, changes in ABI were not associated with changes in cognitive function.

Conclusion: In an older cohort sedentary individuals with dementia and with functional limitations, lower baseline ABI was independently correlated with cognitive function and associated with greater 2-year risk for progression to mild cognitive impairment or probable dementia.

Trial registration: ClinicalTrials.gov NCT01072500.

Keywords: Cognitive function; ankle-brachial index; dementia; peripheral artery disease.

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Conflict of interest statement

CONFLICT OF INTEREST STATEMENT

Conflicts of Interest: None.

Figures

Figure 1
Figure 1
Scatterplot of Composite Cognitive Function Scores at Baseline by ABI with Adjustment for Risk Factors in Table 1. Included Is a Cubic Spline Regression Curve.
See this image and copyright information in PMC

References

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