Drug therapy for heart failure in older patients-what do they want?

Abstract

Chronic heart failure (CHF) is predominantly seen in older patients, and therefore real life medicine often requires the extrapolation of findings from trials conducted in much younger populations. Prescribing patterns and potential benefits in the elderly are heavily influenced by polypharmacy and co-morbid pathologies. Increasing longevity may become less relevant in the frail elderly, whereas improving quality of life (QoL) often becomes priority; the onus being on improving wellbeing, maintaining independence for longer, and delaying institutionalisation. Specific studies evaluating elderly patients with CHF are lacking and little is known regarding the tolerability and side-effect profile of evidence based drug therapies in this population. There has been recent interest on the impact of heart rate in patients with symptomatic CHF. Ivabradine, with selective heart rate lowering capabilities, is of benefit in patients with CHF and left ventricular systolic dysfunction in sinus rhythm, resulting in reduction of heart failure hospitalisation and cardiovascular death. This manuscript will focus on CHF and the older patient and will discuss the impact of heart rate, drug therapies and tolerability. It will also highlight the unmet need for specific studies that focus on patient-centred study end points rather than mortality targets that characterise most therapeutic trials. An on-going study evaluating the impact of ivabradine on QoL that presents a unique opportunity to evaluate the tolerability and impact of an established therapy on a wide range of real life, older patients with CHF will be discussed.

Keywords: Heart failure; Heart rate; Quality of life; The elderly.

Figure 1.. Proposed visit schedule for “Live: Life” participants.

*Ivabradine is indicated: Chronic heart failure NYHA Class II to IV with systolic dysfunction; In sinus rhythm with resting HR ≥ 75 bpm; In combination with standard therapy including beta blockers or when beta blockers are contraindicated or not tolerated. QoL: quality of life; MLHFQ: Minnesota Living with Heart Failure Questionnaire; NYHA: New York Heart Association; 6MWT: 6 minute walk test.