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Review
. 2015 Apr;4(2):110-8.
doi: 10.3978/j.issn.2218-6751.2015.01.01.

Epidermal growth factor receptor in non-small cell lung cancer

Charles N Prabhakar  1
Affiliations
Review

Epidermal growth factor receptor in non-small cell lung cancer

Charles N Prabhakar. Transl Lung Cancer Res. 2015 Apr.

Abstract

Following the identification of a group of patients in the initial tyrosine kinase inhibitor (TKI) trials for lung cancer, there has been detailed focus on which patients may benefit from inhibitor therapy. This article reviews the background, genetics and prevalence of epidermal growth factor mutations in non-small cell lung cancer (NSCLC). Additionally, the prevalence in unselected patients is compared against various other reviews.

Keywords: Lung neoplasms; carcinoma; epidermal growth factor; non-small cell lung cancer (NSCLC); receptor.

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References

    1. Jemal A, Bray F, Center MM, et al. Global cancer statistics. CA Cancer J Clin 2011;61:69-90. - PubMed
    1. Herbst RS, Heymach JV, Lippman SM. Lung cancer. N Engl J Med 2008;359:1367-80. - PMC - PubMed
    1. Travis WD, Brambilla E, Konrad Müller-Hermelink H, et al. eds. Pathology and Genetics of Tumours of the Lung, Pleura, Thymus and Heart. Lyon: IARC Press, 2004:1.
    1. Devesa SS, Bray F, Vizcaino AP, et al. International lung cancer trends by histologic type: male:female differences diminishing and adenocarcinoma rates rising. Int J Cancer 2005;117:294-9. - PubMed
    1. Boyle P, Levin B. eds. World Cancer Report 2008. World Health Organization, 2008:1.