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Review
. 2015 Apr;4(2):126-41.
doi: 10.3978/j.issn.2218-6751.2015.01.10.

Molecular methods for somatic mutation testing in lung adenocarcinoma: EGFR and beyond

Christine Khoo  1 , Toni-Maree Rogers  1 , Andrew Fellowes  1 , Anthony Bell  1 , Stephen Fox  1
Affiliations
Review

Molecular methods for somatic mutation testing in lung adenocarcinoma: EGFR and beyond

Christine Khoo et al. Transl Lung Cancer Res. 2015 Apr.

Abstract

Somatic mutational profiling in cancer has revolutionized the practice of clinical oncology. The discovery of driver mutations in non-small cell lung cancer (NSCLC) is an example of this. Molecular testing of lung adenocarcinoma is now considered standard of care and part of the diagnostic algorithm. This article provides an overview of the workflow of molecular testing in a clinical diagnostic laboratory discussing in particular novel assays that are currently in use for somatic mutation detection in NSCLC focussing on epidermal growth factor receptor (EGFR) mutations and anaplastic lymphoma kinase (ALK), ROS1 and RET rearrangements.

Keywords: Epidermal growth factor receptor (EGFR); RET; ROS1; anaplastic lymphoma kinase (ALK).

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