Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2015 May;44(4):676-8.
doi: 10.1097/MPA.0000000000000311.

HNPCC-associated pheochromocytoma: expanding the tumor spectrum

Brian P Riff  1 , Bryson W Katona, Myra Wilkerson, Katherine L Nathanson, David C Metz
Affiliations
Case Reports

HNPCC-associated pheochromocytoma: expanding the tumor spectrum

Brian P Riff et al. Pancreas. 2015 May.
No abstract available

PubMed Disclaimer

Conflict of interest statement

The Authors Declare No Conflict of Interest

Figures

Figure 1
Figure 1
1A: Hematoxylin and eosin stained section of pheochromocytoma with marked cytologic atypia 1B: Tumor shows diffuse cytoplasmic staining for synaptophysin 1C: Tumor demonstrates presence of mismatch repair proteins MLH-1 1D: Tumor demonstrates presence of PMS-2 1E: Tumor shows loss of mismatch repair proteins MSH-2 (1E) 1F: Tumor shows loss of mismatch repair proteins MSH-6 (1F). * All photos at 400X.
See this image and copyright information in PMC

References

    1. Hampel Heather, et al. Screening for the HNPCC (hereditary nonpolyposis colorectal cancer) New England Journal of Medicine. 2005;352(18):1851–1860. - PubMed
    1. Ligtenberg Marjolijn JL, et al. Heritable somatic methylation and inactivation of MSH2 in families with HNPCC due to deletion of the 3′ exons of TACSTD1. Nature genetics. 2008;41(1):112–117. - PubMed
    1. Vasen HFA, et al. MSH2 mutation carriers are at higher risk of cancer than MLH1 mutation carriers: a study of hereditary nonpolyposis colorectal cancer families. Journal of Clinical Oncology. 2001;19(20):4074–4080. - PubMed
    1. Arnason Thomas, et al. Loss of expression of DNA mismatch repair proteins is rare in pancreatic and small intestinal neuroendocrine tumors. Archives of Pathology & Laboratory Medicine. 2011;135(12):1539–1544. - PubMed
    1. Kidd Mark, et al. Microsatellite instability and gene mutations in transforming growth factor-beta type II receptor are absent in small bowel carcinoid tumors. Cancer. 2005;103(2):229–236. - PubMed

MeSH terms