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. 1989 Nov 11;17(21):8803-19.
doi: 10.1093/nar/17.21.8803.

Sequence-dependent DNA curvature: conformational signal present in the main regulatory region of the rat mitochondrial genome

G Pepe  1 , G Gadaleta, G Palazzo, C Saccone
Affiliations
Free PMC article

Sequence-dependent DNA curvature: conformational signal present in the main regulatory region of the rat mitochondrial genome

G Pepe et al. Nucleic Acids Res. .
Free PMC article

Abstract

Theoretical analysis and experimental approaches by gel electrophoresis in retarding conditions allowed us to identify the presence of an intrinsic bending in the D-loop containing region of the rat mitochondrial genome. The curvature was located in the right domain of the sequence analyzed, between the origin of replication of the heavy strand and its promoter. The preliminary evidence of a specific recognition of the bent DNA with mitochondrial matrix proteins suggests a probable role of this DNA conformation in the duplication and/or expression of the mammalian mitochondrial genome.

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References

    1. CRC Crit Rev Biochem. 1985;19(2):89-106 - PubMed
    1. J Mol Evol. 1989 Jun;28(6):497-516 - PubMed
    1. Nucleic Acids Res. 1987 Jan 26;15(2):785-96 - PubMed
    1. Cell. 1982 Apr;28(4):693-705 - PubMed
    1. Annu Rev Biochem. 1984;53:573-94 - PubMed

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