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. 1989 Nov 25;17(22):9395-405.
doi: 10.1093/nar/17.22.9395.

Structure and functional expression of a cloned Xenopus thyroid hormone receptor

A R Brooks  1 , G Sweeney, R W Old
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Free PMC article

Structure and functional expression of a cloned Xenopus thyroid hormone receptor

A R Brooks et al. Nucleic Acids Res. .
Free PMC article

Abstract

A clone corresponding to a thyroid hormone receptor was isolated from a Xenopus laevis cDNA library prepared from folliculated oocytes. The cDNA encodes a protein of 418 amino acid residues with a domain structure, including a putative DNA binding region with two zinc fingers, similar to other members of the v-erbA-related superfamily of receptors. The encoded protein resembles the TR alpha 1-type receptor of the rat. When expressed in COS cells the protein product binds triiodothyronine with a Kd of 0.12 nM. The receptor mediates thyroid-hormone-inducible expression of a reporter gene which includes a thyroid hormone response element in its upstream region.

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References

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