Amino acid uptake in erythropoiesis
- PMID: 25872868
- DOI: 10.1126/scisignal.aab1203
Amino acid uptake in erythropoiesis
Abstract
Erythroblasts produce huge amounts of hemoglobin, for which they must incorporate vast stores of iron and amino acids. In the 14 April issue of Science Signaling, Chung et al. describe the complex mechanism linking neutral amino acid uptake to hemoglobin production in these hungry cells.
Copyright © 2015, American Association for the Advancement of Science.
Comment on
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The mTORC1/4E-BP pathway coordinates hemoglobin production with L-leucine availability.Sci Signal. 2015 Apr 14;8(372):ra34. doi: 10.1126/scisignal.aaa5903. Sci Signal. 2015. PMID: 25872869 Free PMC article.
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