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Comment
. 2015 Apr 13;27(4):431-3.
doi: 10.1016/j.ccell.2015.03.012.

Designed to kill: novel menin-MLL inhibitors target MLL-rearranged leukemia

Michael W M Kühn  1 , Scott A Armstrong  2
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Designed to kill: novel menin-MLL inhibitors target MLL-rearranged leukemia

Michael W M Kühn et al. Cancer Cell. .
Free article

Abstract

The interaction between menin and oncogenic mixed lineage leukemia (MLL) fusion proteins is required for leukemic transformation and may represent a therapeutic opportunity. In this issue of Cancer Cell, Borkin and colleagues describe the development of highly potent small-molecule inhibitors of this interaction that reverse the leukemic phenotype and prolong survival in murine models of MLL-rearranged leukemia.

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