Comment

. 2015 Apr 13;27(4):437-8.

doi: 10.1016/j.ccell.2015.03.015.

Radiotherapy complements immune checkpoint blockade

Shin Foong Ngiow¹, Grant A McArthur², Mark J Smyth³

Affiliations

¹ Immunology in Cancer and Infection Laboratory, QIMR Berghofer Medical Research Institute, Herston, QLD 4006, Australia; School of Medicine, University of Queensland, Herston, QLD 4006, Australia.
² Cancer Therapeutics Programs, Trescowthick Laboratories, Peter MacCallum Cancer Centre, St. Andrews Place, East Melbourne, VIC 3002, Australia; Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, VIC 3010, Australia.
³ Immunology in Cancer and Infection Laboratory, QIMR Berghofer Medical Research Institute, Herston, QLD 4006, Australia; School of Medicine, University of Queensland, Herston, QLD 4006, Australia. Electronic address: mark.smyth@qimrberghofer.edu.au.

PMID: 25873170
DOI: 10.1016/j.ccell.2015.03.015

Free article

Comment

Radiotherapy complements immune checkpoint blockade

Shin Foong Ngiow et al. Cancer Cell. 2015.

Free article

. 2015 Apr 13;27(4):437-8.

doi: 10.1016/j.ccell.2015.03.015.

Authors

Shin Foong Ngiow¹, Grant A McArthur², Mark J Smyth³

Affiliations

¹ Immunology in Cancer and Infection Laboratory, QIMR Berghofer Medical Research Institute, Herston, QLD 4006, Australia; School of Medicine, University of Queensland, Herston, QLD 4006, Australia.
² Cancer Therapeutics Programs, Trescowthick Laboratories, Peter MacCallum Cancer Centre, St. Andrews Place, East Melbourne, VIC 3002, Australia; Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, VIC 3010, Australia.
³ Immunology in Cancer and Infection Laboratory, QIMR Berghofer Medical Research Institute, Herston, QLD 4006, Australia; School of Medicine, University of Queensland, Herston, QLD 4006, Australia. Electronic address: mark.smyth@qimrberghofer.edu.au.

PMID: 25873170
DOI: 10.1016/j.ccell.2015.03.015

Abstract

Adaptive immune resistance ablates effective anti-tumor immune responses. In a recent issue of Nature, Victor and colleagues describe that anti-PD-L1 combats adaptive immune resistance upon localized radiation plus anti-CTLA-4 therapy. The superior activity of radiation and dual immune checkpoint blockade is mediated by non-redundant immune mechanisms in cancer.

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Radiation and dual checkpoint blockade activate non-redundant immune mechanisms in cancer.
Twyman-Saint Victor C, Rech AJ, Maity A, Rengan R, Pauken KE, Stelekati E, Benci JL, Xu B, Dada H, Odorizzi PM, Herati RS, Mansfield KD, Patsch D, Amaravadi RK, Schuchter LM, Ishwaran H, Mick R, Pryma DA, Xu X, Feldman MD, Gangadhar TC, Hahn SM, Wherry EJ, Vonderheide RH, Minn AJ. Twyman-Saint Victor C, et al. Nature. 2015 Apr 16;520(7547):373-7. doi: 10.1038/nature14292. Epub 2015 Mar 9. Nature. 2015. PMID: 25754329 Free PMC article.

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Radiotherapy complements immune checkpoint blockade

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