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Case Reports
. 2015 Mar 14;8(1):164-8.
doi: 10.1159/000381014. eCollection 2015 Jan-Apr.

EGFR-Mutated Breast Metastasis of Lung Adenocarcinoma: A Case Report

Eric Dansin  1 , Aurélien Carnot  1 , Véronique Servent  2 , Dorothée Daussay  3 , Yves-Marie Robin  3 , Ecaterina Surmei-Pintilie  4 , Géraldine Lauridant  5 , Clothilde Descarpentries  6 , Françoise Révillion  7 , Claire Delattre  8
Affiliations
Case Reports

EGFR-Mutated Breast Metastasis of Lung Adenocarcinoma: A Case Report

Eric Dansin et al. Case Rep Oncol. .

Abstract

Breast metastasis from other primary carcinoma is very rare and could be difficult to identify despite immunohistochemistry analysis. Breast metastasis from lung adenocarcinoma can mimic triple-negative breast cancer. Given the prognosis and therapeutic challenges, a correct diagnosis appears essential, and molecular biomarkers could be useful. We report the case of a 52-year-old woman with a breast mass initially diagnosed as primary breast cancer and secondarily attached to breast metastasis from an EGFR-mutated lung adenocarcinoma. The same activating EGFR mutations were identified in both the primary lung carcinoma and the breast metastasis.

Keywords: Breast metastasis; EGFR mutation; EGFR tyrosine kinase inhibitors; Lung adenocarcinoma; Triple-negative breast cancer.

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Figures

Fig. 1
Fig. 1
Chest CT scan. Massive pleural effusion and left breast mass (arrow).
Fig. 2
Fig. 2
Chest CT scan. Primary lung cancer in the left upper lobe (arrow).
Fig. 3
Fig. 3
Breast biopsy. Histology features (a) and TTF1-positive immunostaining profile (b) for breast metastasis of the lung adenocarcinoma.
Fig. 4
Fig. 4
Chest CT scan. Objective response after 2 months of afatinib (arrow; see fig. 2 for baseline).
See this image and copyright information in PMC

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