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Review
. 2015 Mar 31;7(1):5748.
doi: 10.4081/or.2015.5748. eCollection 2015 Mar 3.

Fungal periprosthetic joint infection of the hip: a systematic review

Benjamin Schoof  1 , Oliver Jakobs  1 , Stefan Schmidl  1 , Till Orla Klatte  2 , Lars Frommelt  3 , Thorsten Gehrke  1 , Matthias Gebauer  1
Affiliations
Review

Fungal periprosthetic joint infection of the hip: a systematic review

Benjamin Schoof et al. Orthop Rev (Pavia). .

Abstract

Periprosthetic joint infection (PJI) is a severe complication of total joint arthroplasty with an incidence of approximately 1%. Due to the high risk of persisting infection, successful treatment of fungal PJI is challenging. The purpose of this study was to gain insight into the current management of fungal PJI of the hip and, by systematically reviewing the cases published so far, to further improve the medical treatment of this serious complication of total hip arthroplasty. Thus, we conducted a systematic review of the available literature concerning fungal PJI in total hip arthroplasty, including 45 cases of fungal PJI. At the moment a two-stage revision procedure is favorable and there is an ongoing discussion on the therapeutic effect of antifungal drug loaded cement spacers on fungal periprosthetic infections of the hip. Due to the fact that there is rare experience with it, there is urgent need to establish guidelines for the treatment of fungal infections of total hip arthroplasty.

Keywords: fungal periprosthetic infection; joint surgery; total hip arthroplasty.

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Conflict of interest statement

Conflict of interest: the authors declare no potential conflict of interest.

Figures

Figure 1.
Figure 1.
A) Concomitant diseases (in %); B) spectrum of pathogens in the 45 reported cases of fungal PJI; C) surgical treatment protocols; D) medicamentous therapy concept; E) administration of antimycotic/antibacterial agents (%); F) locally administered agents (%).
See this image and copyright information in PMC

References

    1. Pulido L, Ghanem E, Joshi A, et al. Periprosthetic joint infection: the incidence, timing, and predisposing factors. Clin Orthop Relat Res 2008;466:1710-5. - PMC - PubMed
    1. Brooks DH, Pupparo F. Successful salvage of a primary total knee arthroplasty infected with Candida parapsilosis. J Arthroplasty 1998;13:707-12. - PubMed
    1. Cushing RD, Fulgenzi WR. Synovial fluid levels of fluconazole in a patient with Candida parapsilosis prosthetic joint infection who had an excellent clinical response. J Arthroplasty 1997;12:950. - PubMed
    1. Levine M, Rehm SJ, Wilde AH. Infection with Candida albicans of a total knee arthroplasty. Case report and review of the literature. Clin Orthop Relat Res 1988;226:235-9. - PubMed
    1. Waldvogel F. Infections associated with indwelling medical devices. 3rd ed Washington DC: ASM Press; 2000.

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