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Review
. 2014;78(6):85-100.
doi: 10.17116/neiro201478685-100.

Modern molecular approaches to diagnosis and treatment of high-grade brain gliomas

[Article in English, Russian]
Affiliations
Free article
Review

Modern molecular approaches to diagnosis and treatment of high-grade brain gliomas

[Article in English, Russian]
G V Pavlova et al. Zh Vopr Neirokhir Im N N Burdenko. 2014.
Free article

Abstract

The review analyzes the current state of the problem of diagnosis and therapy of high-grade gliomas on the basis of the most promising present-day approaches. The diagnostic and treatment perspectives of the molecular genetic analysis of glioblastoma markers located on the tumor cell surface are considered. Gene therapy and the use of dendritic cells and oncolytic viruses are considered as the most interesting approaches to therapy of high-grade gliomas.

Анализируется современное состояние проблемы диагностики и терапии глиом высокой степени злокачественности с позиции существующих на сегодняшний день наиболее перспективных подходов. Рассматривается перспективность применения в целях диагностики и терапии молекулярно-генетического анализа маркеров глиобластомы, расположенных на поверхности опухолевой клетки. В качестве наиболее интересных подходов к терапии анализируется применение генотерапии, лечения с помощью дендритных клеток и онколитических вирусов. Работа поддержана грантом РФФИ 13-04-40202-Н КОМФИ (13-04-40200-Н, 13-04-40203-Н, 13-04-40201-Н , 13-04-40202-Н), программой МКБ.

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