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Review
. 2015 Jun-Jul;29(5):253-7.
doi: 10.1155/2015/967683. Epub 2015 Apr 15.

Renal impairment in cirrhosis unrelated to hepatorenal syndrome

Gavin Low, Graeme Jm Alexander, David J Lomas
Review

Renal impairment in cirrhosis unrelated to hepatorenal syndrome

Gavin Low et al. Can J Gastroenterol Hepatol. 2015 Jun-Jul.

Abstract
in English, French

Renal impairment is common in liver disease and may occur as a consequence of the pathophysiological changes that underpin cirrhosis or secondary to a pre-existing unrelated insult. Nevertheless, the onset of renal impairment often portends a worsening prognosis. Hepatorenal syndrome remains one of the most recognized and reported causes of renal impairment in cirrhosis. However, other causes of renal impairment occur and can be classified into prerenal, intrinsic or postrenal, which are the subjects of the present review.

L’atteinte rénale est courante dans le contexte d’une maladie hépatique. Elle peut découler des changements physiopathologiques de la cirrhose ou d’un problème préexistant non lié. Elle sous-tend souvent un pronostic plus sombre. Le syndrome hépatorénal demeure l’une des causes d’atteinte rénale les plus connues et les plus signalées en cas de cirrhose. La présente analyse porte sur les autres causes possibles, qui sont d’étiologie pré-rénale, intrinsèque ou post-rénale.

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Figures

Figure 1)
Figure 1)
Types of renal impairment in hospitalized patients with cirrhosis. AKI Acute kidney injury; ARF Acute renal failure; ATN Acute tubular necrosis; GMN Glomerulonephritis; HRS Hepatorenal syndrome. Adapted and reproduced with permission from reference
Figure 2)
Figure 2)
The authors’ simplified diagnostic algorithm for the clinical work-up of renal impairment in patients with cirrhosis. HRS Hepatorenal syndrome
See this image and copyright information in PMC

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