Epigenetics: Characterizing enhancers with dCas9

Comment

Eytan Zlotorynski. Nat Rev Mol Cell Biol. 2015 May.

. 2015 May;16(5):266-7.

doi: 10.1038/nrm3983. Epub 2015 Apr 15.

No abstract available

Comment on

Functional annotation of native enhancers with a Cas9-histone demethylase fusion.
Kearns NA, Pham H, Tabak B, Genga RM, Silverstein NJ, Garber M, Maehr R. Kearns NA, et al. Nat Methods. 2015 May;12(5):401-403. doi: 10.1038/nmeth.3325. Epub 2015 Mar 16. Nat Methods. 2015. PMID: 25775043 Free PMC article.
Epigenome editing by a CRISPR-Cas9-based acetyltransferase activates genes from promoters and enhancers.
Hilton IB, D'Ippolito AM, Vockley CM, Thakore PI, Crawford GE, Reddy TE, Gersbach CA. Hilton IB, et al. Nat Biotechnol. 2015 May;33(5):510-7. doi: 10.1038/nbt.3199. Epub 2015 Apr 6. Nat Biotechnol. 2015. PMID: 25849900 Free PMC article.