Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Randomized Controlled Trial
. 2015 Apr 13;10(4):e0122371.
doi: 10.1371/journal.pone.0122371. eCollection 2015.

The clinical effect of deferoxamine mesylate on edema after intracerebral hemorrhage

Yao Yu  1 , Wei Zhao  2 , Chunpeng Zhu  2 , Zhiping Kong  2 , Yan Xu  1 , Guangzhi Liu  1 , Xuguang Gao  1
Affiliations
Randomized Controlled Trial

The clinical effect of deferoxamine mesylate on edema after intracerebral hemorrhage

Yao Yu et al. PLoS One. .

Abstract

Background and purpose: It has been shown that 3 days of 62 mg/kg/day deferoxamine infusion (maximum dose not to exceed 6000 mg/day) is safe and tolerated by intracerebral hemorrhage (ICH) patients. The aim of this study was to investigate the efficacy of deferoxamine mesylate for edema resolution and hematoma absorption after ICH.

Methods: From February 2013 to May 2014, spontaneous ICH patients diagnosed by computed tomography (CT) within 18 hours of onset were evaluated. Patients were randomly divided into two groups: an experimental group and a control group. The treatment of the two groups was similar except that the experimental group received deferoxamine mesylate. Patients were evaluated by CT and neurology scale at the time of admission, and on the fourth, eighth, and fifteenth day (or at discharge) after admission. Patients were followed up for the first 30 days and clinical data of the two groups were compared.

Results: Forty-two patients completed 30 days of follow-up by May 2014; 21 cases in the experimental group and 21 cases in the control group. The control group's relative edema volume on the fifteenth day (or discharge) was 10.26 ± 17.54, which was higher than the experimental group (1.91 ± 1.94; P < 0.05). The control group's 1-8 day and 8-15 day relative hematoma absorption were greater than the experimental group (P < 0.05).The control group's relative edema volume on the fourth, eighth, and fifteenth day (or discharge) was higher than the experimental group (P < 0.05). Neurological scores between the two groups were not statistically different on the fifteenth day (or discharge) or on the thirtieth day.

Conclusions: Deferoxamine mesylate may slow hematoma absorption and inhibit edema after ICH, although further investigation is required to form definitive conclusions.

Trial registration: Chinese Clinical Trial Registry ChiCTR-TRC-14004979.

PubMed Disclaimer

Conflict of interest statement

Competing Interests: The authors have declared that no competing interests exist.

Figures

Fig 1
Fig 1. Trends in hematoma volume at admission, and on the 4th, 8th, and 15th day (or discharge).
Fig 2
Fig 2. Trends in relative edema volume at admission, and on the 4th, 8th, and 15th day (or discharge).
See this image and copyright information in PMC

References

    1. Feigin VL, Lawes CM, Bennett DA, Barker-Collo SL, Parag V. Worldwide stroke incidence and early case fatality reported in 56 population-based studies: a systematic review. Lancet Neurol.2009; 8:355–369. 10.1016/S1474-4422(09)70025-0 - DOI - PubMed
    1. Feigin VL, Lawes CM, Bennett DA, Anderson CS. Stroke epidemiology: a review of population-based studies of incidence, prevalence, and case-fatality in the late 20th century. Lancet Neurol. 2004; 2:43–53. - PubMed
    1. Qureshi AI, Mendelow AD, Hanley DF.Intracerebral haemorrhage. Lancet. 2009;373: 1632–44. 10.1016/S0140-6736(09)60371-8 - DOI - PMC - PubMed
    1. Xi G, Keep RF, Hoff JT. Mechanisms of brain injury after intracerebral haemorrhage. Lancet Neurol.2006; 5: 53–63. - PubMed
    1. Arima H, Wang JG, Huang Y, Heeley E, Skulina C,Parsons MW, et al. Significance of perihematomal edema in acute intracerebral hemorrhage: the INTERACT trial. Neurology. 2009;73: 1963–1968. 10.1212/WNL.0b013e3181c55ed3 - DOI - PMC - PubMed

Publication types

LinkOut - more resources