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. 2015 Apr 13;10(4):e0124045.
doi: 10.1371/journal.pone.0124045. eCollection 2015.

Different levels in alcohol and tobacco consumption in head and neck cancer patients from 1957 to 2013

Yu Zhang  1 , Ruixia Wang  2 , Limin Miao  3 , Longbiao Zhu  2 , Hongbing Jiang  1 , Hua Yuan  1
Affiliations

Different levels in alcohol and tobacco consumption in head and neck cancer patients from 1957 to 2013

Yu Zhang et al. PLoS One. .

Abstract

Objective: To provide a precise quantification of the association between alcohol and tobacco consumption trends in head and neck cancer patients over the past 45 years.

Methods: We combined findings from all studies published until March 2014 and evaluated the association between different levels in alcohol and tobacco consumption and head and neck cancers through a meta-analytic approach.

Results: We included 28 studies involving 13830 patients with head and neck cancer. In patients with alcohol consumption, the pooled odds ratio (OR) and 95% confidence interval (CI) were 1.29(1.06-1.57), 2.67(2.05-3.48) and 6.63(5.02-8.74) for light drinkers, moderate drinkers and heavy drinkers, respectively. In patients with tobacco consumption, the pooled OR and 95% CI were 2.33(1.84-2.95), 4.97(3.67-6.71) and 6.77(4.81-9.53) for light smokers, moderate smokers and heavy smokers, respectively.

Conclusion: The increased alcohol and tobacco consumption trends increased the risk of head and neck cancer over the past 45 years. Tobacco consumption was found to be a stronger risk factor for head and neck cancer than alcohol consumption. Thus, the control should be considered to limit the intake of alcohol and tobacco.

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Conflict of interest statement

Competing Interests: The authors would like to declare that no competing interests exist.

Figures

Fig 1
Fig 1. Flowchart of selection of studies for inclusion in meta-analysis.
Fig 2
Fig 2. Forest plots for pooled Odds ratios (ORs) and the corresponding 95% confidence intervals (CIs) of HNC cancer risks for light, moderate and heavy drinkers.
Fig 3
Fig 3. Relative risk function and 95% confidence intervals for the association between alcohol consumption per day and HNC.
Fig 4
Fig 4. Forest plots for pooled Odds ratios (ORs) and the corresponding 95% confidence intervals (CIs) of HNC cancer risks for light, moderate and heavy smokers.
Fig 5
Fig 5. Relative risk function and the 95% confidence intervals for the association between tobacco consumption per day and HNC.
See this image and copyright information in PMC

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