[Prevalence of dyslipidemia in Chinese children and adolescents:a Meta-analysis]

Abstract

Objective: To quantify the prevalence of dyslipidemia among children and adolescents in China.

Methods: Chinese Biomedical Database (CBM), Wanfang Databases, China National Knowledge Infrastructrue (CNKI) and PubMed were comprehensively searched. Original reports were selected if data on prevalence estimates of dyslipdemia among children and adolescents in China, was provided under cross-sectional epidemiological studies. Quality of the literature was evaluated through the STROBE statement. The prevalence through Meta was estimated using the Strata 11.0 software. Subgroup analysis was undertaken on gender, age, regions and secular trends issues. Sensitivity analysis was performed to evaluate the impact of quality or standard of diagnosis.

Results: A total of 24 papers were included in this Meta-analysis, with the whole sample size as 129 426. The overall pooled-prevalence of total dsylipidemia was estimated at 25.3% (95% CI: 12.7%-37.8%). Prevalence rates of high TC, LDL-C, TG, low HDL-C and hyperlipemia were 4.1% (95% CI:3.4%-4.9%), 5.3% (95% CI:3.9%-6.7%), 8.5% (95% CI:6.3%-10.7%), 6.8% (95% CI: 3.7%-9.9%), 4.8% (95%CI:0.6%-9.1%), respectively. Girls (3.4%) had lower prevalence of high TG than boys (5.6%), but having higher prevalence of other different types dyslipidemia. Children aged 7-18 years had higher overall prevalence of dyslipidemia (31.6%) when compared to children aged 2-6 years (9.0%). There were no statistically significant differences for subgroups of age, region and period regarding the prevalence rates of high TG, TC and low HDL-C(P > 0.05).

Conclusion: Prevalence of dyslipidemia was high and with increasing trend among children and adolescents in China. Early screening and prevention programs on abnormal serum lipids should be emphasized and promoted.