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. 2015 Apr 16;520(7547):307-11.
doi: 10.1038/nature14397.

A resource for cell line authentication, annotation and quality control

Mamie Yu  1 , Suresh K Selvaraj  1 , May M Y Liang-Chu  1 , Sahar Aghajani  2 , Matthew Busse  2 , Jean Yuan  2 , Genee Lee  1 , Franklin Peale  3 , Christiaan Klijn  2 , Richard Bourgon  2 , Joshua S Kaminker  2 , Richard M Neve  1
Affiliations

A resource for cell line authentication, annotation and quality control

Mamie Yu et al. Nature. .

Abstract

Cell line misidentification, contamination and poor annotation affect scientific reproducibility. Here we outline simple measures to detect or avoid cross-contamination, present a framework for cell line annotation linked to short tandem repeat and single nucleotide polymorphism profiles, and provide a catalogue of synonymous cell lines. This resource will enable our community to eradicate the use of misidentified lines and generate credible cell-based data.

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