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Review
. 2015 Apr 15;5(8):a021147.
doi: 10.1101/cshperspect.a021147.

Tuberculosis Drug Development: History and Evolution of the Mechanism-Based Paradigm

Sumit Chakraborty  1 , Kyu Y Rhee  1
Affiliations
Review

Tuberculosis Drug Development: History and Evolution of the Mechanism-Based Paradigm

Sumit Chakraborty et al. Cold Spring Harb Perspect Med. .

Abstract

Modern tuberculosis (TB) chemotherapy is widely viewed as a crowning triumph of anti-infectives research. However, only one new TB drug has entered clinical practice in the past 40 years while drug resistance threatens to further destabilize the pandemic. Here, we review a brief history of TB drug development, focusing on the evolution of mechanism(s)-of-action studies and key conceptual barriers to rational, mechanism-based drugs.

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Figures

Figure 1.
Figure 1.
Antitubercular compounds.
See this image and copyright information in PMC

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