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Comment
. 2015 Jun;5(6):571.
doi: 10.1158/2159-8290.CD-NB2015-053. Epub 2015 Apr 15.

Tetanus shot may improve glioblastoma treatment

No authors listed
Comment

Tetanus shot may improve glioblastoma treatment

No authors listed. Cancer Discov. 2015 Jun.

Abstract

Preconditioning the immune system with a tetanus/diphtheria toxoid significantly improved the effectiveness of dendritic cell immunotherapy and extended overall survival in a small, randomized study of patients with glioblastoma.

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  • Tetanus toxoid and CCL3 improve dendritic cell vaccines in mice and glioblastoma patients.
    Mitchell DA, Batich KA, Gunn MD, Huang MN, Sanchez-Perez L, Nair SK, Congdon KL, Reap EA, Archer GE, Desjardins A, Friedman AH, Friedman HS, Herndon JE 2nd, Coan A, McLendon RE, Reardon DA, Vredenburgh JJ, Bigner DD, Sampson JH. Mitchell DA, et al. Nature. 2015 Mar 19;519(7543):366-9. doi: 10.1038/nature14320. Epub 2015 Mar 11. Nature. 2015. PMID: 25762141 Free PMC article. Clinical Trial.

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