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. 2015 Jul;53(7):2324-8.
doi: 10.1128/JCM.00727-15. Epub 2015 Apr 15.

Coproduction of KPC-2 and IMP-10 in Carbapenem-Resistant Serratia marcescens Isolates from an Outbreak in a Brazilian Teaching Hospital

Kesia Esther Silva  1 , Rodrigo Cayô  2 , Cecilia Godoy Carvalhaes  2 , Flávia Patussi Correia Sacchi  3 , Fernanda Rodrigues-Costa  2 , Ana Carolina Ramos da Silva  2 , Julio Croda  4 , Ana Cristina Gales  2 , Simone Simionatto  5
Affiliations

Coproduction of KPC-2 and IMP-10 in Carbapenem-Resistant Serratia marcescens Isolates from an Outbreak in a Brazilian Teaching Hospital

Kesia Esther Silva et al. J Clin Microbiol. 2015 Jul.

Abstract

We describe an outbreak caused by KPC-2- and IMP-10-producing Serratia marcescens isolates in a Brazilian teaching hospital. Tigecycline was the only active antimicrobial agent tested. The blaIMP-10 gene was located in a new class 1 integron, named In990, carried by a nonconjugative plasmid, in contrast to blaKPC-2.

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Figures

FIG 1
FIG 1
Dendrogram displaying the genetic relatedness of 24 carbapenem-resistant S. marcescens isolates recovered during an outbreak in the ICUs of a Brazilian teaching hospital according to the PFGE data and carbapenemase content.
See this image and copyright information in PMC

References

    1. Iosifidis E, Farmaki E, Nedelkopoulou N, Tsivitanidou M, Kaperoni M, Pentsoglou V, Pournaras S, Athanasiou-Metaxa M, Roilides E. 2012. Outbreak of bloodstream infections because of Serratia marcescens in a pediatric department. Am J Infect Control 40:11–15. doi:10.1016/j.ajic.2011.03.020. - DOI - PubMed
    1. de Vries JJ, Baas WH, van der Ploeg K, Heesink A, Degener JE, Arends JP. 2006. Outbreak of Serratia marcescens colonization and infection traced to a healthcare worker with long-term carriage on the hands. Infect Control Hosp Epidemiol 27:1153–1158. doi:10.1086/508818. - DOI - PubMed
    1. Samonis G, Korbila IP, Maraki S, Michailidou I, Vardakas KZ, Kofteridis D, Dimopoulou D, Gkogkozotou VK, Falagas ME. 2014. Trends of isolation of intrinsically resistant to colistin Enterobacteriaceae and association with colistin use in a tertiary hospital. Eur J Clin Microbiol Infect Dis 33:1505–1510. doi:10.1007/s10096-014-2097-8. - DOI - PubMed
    1. Ribeiro VB, Andrade LN, Linhares AR, Barin J, Darini AL, Zavascki AP, Barth AL. 2013. Molecular characterization of Klebsiella pneumoniae carbapenemase-producing isolates in southern Brazil. J Med Microbiol 62:1721–1727. doi:10.1099/jmm.0.062141-0. - DOI - PubMed
    1. da Costa Guimarães AC, Almeida AC, Nicoletti AG, Vilela MA, Gales AC, de Morais MM. 2013. Clonal spread of carbapenem-resistant Serratia marcescens isolates sharing an IncK plasmid containing blaKPC-2. Int J Antimicrob Agents 42:369–370. doi:10.1016/j.ijantimicag.2013.05.017. - DOI - PubMed

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