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Review
. 2015 Mar;7(3):75-80.

The role of myofibroblasts in wound healing, contraction and its clinical implications in cleft palate repair

Ravi Teja Chitturi  1 , A Murali Balasubramaniam  2 , R Arjun Parameswar  3 , G Kesavan  4 , K T Muhamed Haris  5 , Khadijah Mohideen  2
Affiliations
Review

The role of myofibroblasts in wound healing, contraction and its clinical implications in cleft palate repair

Ravi Teja Chitturi et al. J Int Oral Health. 2015 Mar.

Abstract

Myofibroblasts after its discovery in 1971 as the principal cell for wound healing has come a long way as far as research is concerned. The primary focus of research has been regarding preventing certain unwanted effects of this cell such as wound contraction and scarring. As far as the oral and maxillofacial region is concerned, the primary concern of this untoward effect is during repair of cleft palate surgically which results impaired development of palate and the dentoalveolar structures. This review focuses on the basic aspects of myofibroblasts such as its origin, formation, function in wound healing, role in wound contraction and ways by which its unwanted effects can be overcome to improve the quality of the post surgical complications of cleft palate surgery.

Keywords: Cleft palate; complications of wound healing; factors affecting myofibroblasts; myofibroblasts; wound healing.

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Conflict of interest statement

Conflicts of Interest: None

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