Mimicking membrane-related biological events by DNA origami nanotechnology

Abstract

One of the potential applications of DNA nanotechnology is the construction of two- or three-dimensional nanostructures that mimic the function of existing biological molecules. In this issue of ACS Nano, Kocabey et al. demonstrate that lipid-bilayer-anchored DNA origami structures can be assembled into prescribed superstructures in a programmed manner. The reported DNA-based artificial system can mimic the dynamic assembly of membrane-associated protein clusters that play an essential role in deformation of cellular membranes.