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Editorial
. 2015;14(9):1343-4.
doi: 10.1080/15384101.2015.1024583.

p53 orchestrates calcium signaling in vivo

Giovanni Sorrentino  1 , Anna Comel, Giannino Del Sal
Affiliations
Editorial

p53 orchestrates calcium signaling in vivo

Giovanni Sorrentino et al. Cell Cycle. 2015.
No abstract available

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Figures

Figure 1.
Figure 1.
Intravital imaging of ER-mitochondrial Ca2+ transfer and its regulation by p53. Ca2+ is transferred to the ER by the SERCA pumps and is released by inositol 1,4,5-triphosphate (IP3)-gated channels (IP3R). p53 binds and activates SERCA pumps thus increasing the amount of Ca2+ storage into the ER. The Ca2+ released to the mitochondria after phototherapy leads to mitochondrial swelling with consequent apoptosis induction in p53+/+ tumors.
See this image and copyright information in PMC

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