Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2015 Apr;30(2):210-6.
doi: 10.1007/s12291-014-0429-1. Epub 2014 Apr 19.

Monitoring coagulation proteins during progression of liver disease

Mohamed Hessien  1 , Mohamed Ayad  2 , Wafaa M Ibrahim  3 , Batoul Izz ulArab  2
Affiliations

Monitoring coagulation proteins during progression of liver disease

Mohamed Hessien et al. Indian J Clin Biochem. 2015 Apr.

Abstract

This work was designated to monitor the coagulation abnormalities associated with the gradual progression of liver diseases. The study included fifty patients; forty were diagnosed with liver cirrhosis with different stages categorized according to the Childs-Pugh classification and another ten patients were diagnosed with hepatocellular carcinoma (HCC). Haemostatic variables including fibrinogen (FI), calcium (FIV), transglutaminase (FXIII), prothrombin time (PT) and platelet count were estimated in patients and compared with the baseline levels of healthy subjects (n = 10). The results demonstrated that the fibrinogen level was progressively decreased, whereas PT was progressively prolonged in Child A, Child B and Child C groups. The maximum deterioration was observed in HCC patients. Calcium significantly increased in mild (Child A) and moderate (Child B) but not in Child C cirrhosis and HCC patients. FXIII level did not show any significant changes in cirrhotic patients compared to healthy group. Some of the haemostatic variables we investigated were correlated with serum albumin and bilirubin but not with aminotransferases (ALT and AST). The results indicated that the haemostatic abnormalities in fibrinogen, calcium and PT (but not FXIII) were deteriorated in parallel with the gradual regression of the constitutional function of liver.

Keywords: Coagulation factors; FIV; FXIII; Fibrinogen; HCC; Liver cirrhosis; Prothrombin time.

PubMed Disclaimer

Figures

Fig. 1
Fig. 1
Mean values of serum aminotransaminases (ALT and AST) in normal, cirrhotic and HCC patients
See this image and copyright information in PMC

References

    1. Muciño-Bermejo J, Carrillo-Esper R, Uribe M, Méndez-Sánchez N. Coagulation abnormalities in the cirrhotic patient. Ann Hepatol. 2013;12(5):713–724. - PubMed
    1. Páramo JA, Rocha E. Hemostasis in advanced liver disease. Semin Thromb Hemost. 1993;19(3):184–90. - PubMed
    1. Pugh RN, Murray-Lyon IM, Dawson JL, Pietroni MC, Williams R. Transection of the esophagus for bleeding esophageal varices. Br J Surg. 1973;60:646–649. doi: 10.1002/bjs.1800600817. - DOI - PubMed
    1. Solomon L. Hematologic complications of liver disease and alcoholism. In: Hoffman R, Benz E, editors. Basic principles and practice of hematology. New York: Churchill Livingstone; 1994.
    1. Amitrano L, Guardascione MA, Brancaccio V, Balzano A. Coagulation disorders in liver disease. Semin Liver Dis. 2002;22(1):83–96. doi: 10.1055/s-2002-23205. - DOI - PubMed

LinkOut - more resources