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. 2015 Apr 10:15:39.
doi: 10.1186/s12935-015-0187-z. eCollection 2015.

The role of death-associated protein 3 in apoptosis, anoikis and human cancer

Umar Wazir  1 , Mona Maw Orakzai  2 , Zubair S Khanzada  3 , Wen G Jiang  3 , Anup K Sharma  4 , Abdul Kasem  5 , Kefah Mokbel  1
Affiliations

The role of death-associated protein 3 in apoptosis, anoikis and human cancer

Umar Wazir et al. Cancer Cell Int. .

Abstract

Death-associated protein 3 (DAP3) is a molecule with a significant role in the control of both apoptosis and anoikis. Apoptosis is the predominant type of programmed cell death (PCD) which may occur in response to irreparable damage to DNA, or in response to induction by inflammatory cells. Anoikis is subset of apoptosis which occurs in epithelial cells in response to detachment from the surrounding matrix. Both apoptosis and anoikis are of interest in the context of carcinogenesis. In this review, we shall discuss apoptosis and anoikis, and the recent literature regarding the role of DAP3 in both these pathways.

Keywords: Anoikis; Apoptosis; Breast cancer; Cancer; Carcinogenesis; Death-associated protein 3; Oncogenesis; Review.

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Figures

Figure 1
Figure 1
Schematic representation of the relation of DAP3 and DELE with Fas receptor related DISC. AKT/PKB: protein kinase B, CARD: caspase activation and recruitment domain, DAP3: death-associated protein 3, DD: death domains, DED: death effector domains, DELE: death ligand signal enhancer, DR: death receptor, DISC: death inducing signalling complex, FADD: Fas Associated Death, FLICE: FADD-like interleukin-1 beta-converting enzyme, FLIP: FLICE inhibitory protein.
Figure 2
Figure 2
General scheme illustrating the internal, external and perforin/granzyme pathways within apoptosis, including the sub-programmes specific to anoikis and DAP3. AKT/PKB: protein kinase B, CARD: caspase activation and recruitment domain, DAP3: death-associated protein 3, DD: death domains, DED: death effector domains, DELE: death ligand signal enhancer, DR: death receptor, DISC: death inducing signalling complex, FADD: Fas Associated Death, FLICE: FADD-like interleukin-1 beta-converting enzyme, IPS: 1interferon-β promoter stimulator 1.
Figure 3
Figure 3
Schematic representation of the relation of DAP3 and IPS1 on mitochondrial surface. AKT/PKB: protein kinase B, CARD: caspase activation and recruitment domain, DAP3: death-associated protein 3, DD: death domains, DED: death effector domains, DELE: death ligand signal enhancer, DR: death receptor, DISC: death inducing signalling complex, FADD: Fas Associated Death, FLICE: FADD-like interleukin-1 beta-converting enzyme, FLIP: FLICE inhibitory protein, IPS: 1interferon-β promoter stimulator 1.
See this image and copyright information in PMC

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