Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2015:2015:137287.
doi: 10.1155/2015/137287. Epub 2015 Mar 25.

Biomaterial hypersensitivity: is it real? Supportive evidence and approach considerations for metal allergic patients following total knee arthroplasty

Andrew J Mitchelson  1 , Craig J Wilson  1 , William M Mihalko  2 , Thomas M Grupp  3 , Blaine T Manning  1 , Douglas A Dennis  4 , Stuart B Goodman  5 , Tony H Tzeng  1 , Sonia Vasdev  1 , Khaled J Saleh  1
Affiliations
Review

Biomaterial hypersensitivity: is it real? Supportive evidence and approach considerations for metal allergic patients following total knee arthroplasty

Andrew J Mitchelson et al. Biomed Res Int. 2015.

Abstract

The prospect of biomaterial hypersensitivity developing in response to joint implant materials was first presented more than 30 years ago. Many studies have established probable causation between first-generation metal-on-metal hip implants and hypersensitivity reactions. In a limited patient population, implant failure may ultimately be related to metal hypersensitivity. The examination of hypersensitivity reactions in current-generation metal-on-metal knee implants is comparatively limited. The purpose of this study is to summarize all available literature regarding biomaterial hypersensitivity after total knee arthroplasty, elucidate overall trends about this topic in the current literature, and provide a foundation for clinical approach considerations when biomaterial hypersensitivity is suspected.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Figure 2
Figure 2
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Elves M. W., Wilson J. N., Scales J. T., Kempt H. B. S. Incidence of metal sensitivity in patients with total joint replacements. British Medical Journal. 1975;4(5993):376–378. doi: 10.1136/bmj.4.5993.376. - DOI - PMC - PubMed
    1. Evans E. M., Freeman M. A. R., Miller A. J., Vernon Roberts B. Metal sensitivity as a cause of bone necrosis and loosening of the prosthesis in total joint replacement. Journal of Bone and Joint Surgery—Series B. 1974;56(4):626–642. - PubMed
    1. Cousen P. J., Gawkrodger D. J. Metal allergy and second-generation metal-on-metal arthroplasties. Contact Dermatitis. 2012;66(2):55–62. doi: 10.1111/j.1600-0536.2011.01970.x. - DOI - PubMed
    1. Basko-Plluska J. L., Thyssen J. P., Schalock P. C. Cutaneous and systemic hypersensitivity reactions to metallic implants. Dermatitis. 2011;22(2):65–79. doi: 10.2310/6620.2011.10055. - DOI - PubMed
    1. Schalock P. C., Menné T., Johansen J. D., et al. Hypersensitivity reactions to metallic implants—diagnostic algorithm and suggested patch test series for clinical use. Contact Dermatitis. 2012;66(1):4–19. doi: 10.1111/j.1600-0536.2011.01971.x. - DOI - PubMed

LinkOut - more resources