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. 2015:2015:651218.
doi: 10.1155/2015/651218. Epub 2015 Mar 25.

Therapeutic effect of Agaricus brasiliensis on phenylhydrazine-induced neonatal jaundice in rats

Lan Zhang  1 , Bo Yuan  2 , HuiPing Wang  1 , Ya Gao  1
Affiliations

Therapeutic effect of Agaricus brasiliensis on phenylhydrazine-induced neonatal jaundice in rats

Lan Zhang et al. Biomed Res Int. 2015.

Abstract

The present study was designed to investigate the effect of Agaricus brasiliensis extract (ABE) on phenylhydrazine-induced neonatal jaundice in rats. Administration of ABE dose-dependently reduced the elevated bilirubin level induced by phenylhydrazine. It can be somewhat supported from the results of in vitro bilirubin degradation experiment. ABE treatment also reduced the total antioxidant status (TAOS), cascade O2(-)/SOD, level of NF-κB protein, and adrenomedullin (AM). Overall, the results of this study demonstrated that Agaricus brasiliensis extract may be beneficial to reducing bilirubin level without causing hepatotoxicity in neonatal jaundice.

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Figures

Figure 1
Figure 1
Comparison of in vitro efficacy of bilirubin degradation between different concentrations of ABE. Values are shown as means ± SEM. * P < 0.05 versus control group, ** P < 0.01 versus control group.
Figure 2
Figure 2
Histopathological analysis of rat liver sections using hematoxylin and eosin staining. (a) Section from a normal control rat liver. (b) Section from ABE-100 rat liver. (c) Section from ABE-50 rat liver. (d) Section from ABE-20 rat liver. (e) Section from a phenylhydrazine rat liver.
Figure 3
Figure 3
Effect of ABE on cascade of O2 −/SOD values. Values are shown as means ± SEM. * P < 0.05 versus phenylhydrazine, ** P < 0.01 versus phenylhydrazine group (Pdz: phenylhydrazine).
Figure 4
Figure 4
Effect of ABE on protein expression of NF-κB. Values represent the mean ± SEM. * P < 0.05 versus phenylhydrazine group (Pdz: phenylhydrazine).
Figure 5
Figure 5
Correlation between serum AM levels and serum bilirubin levels.
See this image and copyright information in PMC

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