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Review
. 2015:2015:729076.
doi: 10.1155/2015/729076. Epub 2015 Mar 26.

Design, materials, and mechanobiology of biodegradable scaffolds for bone tissue engineering

Marco A Velasco  1 , Carlos A Narváez-Tovar  2 , Diego A Garzón-Alvarado  3
Affiliations
Review

Design, materials, and mechanobiology of biodegradable scaffolds for bone tissue engineering

Marco A Velasco et al. Biomed Res Int. 2015.

Abstract

A review about design, manufacture, and mechanobiology of biodegradable scaffolds for bone tissue engineering is given. First, fundamental aspects about bone tissue engineering and considerations related to scaffold design are established. Second, issues related to scaffold biomaterials and manufacturing processes are discussed. Finally, mechanobiology of bone tissue and computational models developed for simulating how bone healing occurs inside a scaffold are described.

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Figures

Figure 1
Figure 1
Graphic representation of mechanoregulatory models proposed by (a) Pauwels [204], (b) Carter et al. [200], (c) Claes and Heigele [201], and (d) Prendergast [205]. Adapted from Geris et al. [34] with permission from the Royal Society.
Figure 2
Figure 2
Rate of bone change as a function of the strain energy density (U). From Frost [197].
See this image and copyright information in PMC

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