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Comment
. 2015 Apr 16;58(2):199-201.
doi: 10.1016/j.molcel.2015.03.035.

Life after MOMP

Vivian Gama  1 , Mohanish Deshmukh  2
Affiliations
Comment

Life after MOMP

Vivian Gama et al. Mol Cell. .

Abstract

In this and a recent issue of Molecular Cell, Liu et al. (2015) and Ichim et al. (2015) report that low levels of caspase activity triggered by limited mitochondrial outer membrane permeabilization (MOMP) promote genomic instability that drives tumorigenesis, providing a novel and unexpected link between these effectors of apoptosis and cancer initiation.

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Figures

Figure 1
Figure 1. Multiple facets of adenosine signaling
New evidence from Long et al. implicates adenosine as a signaling molecule sensed by cells to trigger cell death. Adenosine is recognized by the ADORA2B receptor (A2BR’), a target of p53. Adenosine signaling induces the upregulation of PUMA and the downregulation of the anti-apoptotic proteins Bcl-2 and Bcl-XL, resulting in apoptosis.
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