HIV-1 subtype B-infected MSM may have driven the spread of transmitted resistant strains in France in 2007-12: impact on susceptibility to first-line strategies

Pierre Frange¹, Lambert Assoumou², Diane Descamps³, Antoine Chéret⁴, Cécile Goujard⁵, Laurent Tran⁶, Marine Gousset⁷, Veronique Avettand-Fenoël⁸, Laurence Bocket⁹, Samira Fafi-Kremer¹⁰, Jerome Guinard¹¹, Laurence Morand-Joubert¹², Florence Nicot¹³, Jean-Christophe Plantier¹⁴, Sylvie Rogez¹⁵, Marc Wirden¹⁶, Christine Rouzioux⁸, Laurence Meyer⁶, Marie-Laure Chaix¹⁷; French ANRS CO 6 PRIMO Cohort, the ANRS 147 OPTIPRIM Clinical Trial and the AC11 Resistance Study Groups; French ANRS CO 6 PRIMO Cohort the ANRS 147 OPTIPRIM Clinical Trial and the AC11 Resistance Study Groups

Collaborators, Affiliations

Collaborators

S Abel, B Abraham, T Allegre, A Antoniotti, R Armero, B Audhuy, H Aumaitre, G Beaucaire, G Beck-Wirth, J L Berger, L Bernard, C Beuscart, L Bodard, O Bouchaud, F Boué, J-P Cabane, A Cabie, H Champagne, C Cheneau, J-M Chennebault, A Cheret, B Christian, A Compagnucci, V Daneluzzi, Y Debab, P Dellamonica, J-F Delfraissy, A Devidas, G Diab, J Doll, M C Drobacheff-Thebaut, A Durel, C Duvivier, J-L Esnault, L Faba, E Froguel, D Garipuy, V Garrait, L Geffray, C Genet, P Genet, L Gerard, J Ghosn, J-J Girard, P-M Girard, C Godin-Collet, P Hochedez, B Hoen, D Houlbert, C Jacomet, V Jeantils, K Jidar, C Katlama, E Klement, A Lafeuillade, C Lascoux, V Launay, A Lepretre, Y Levy, D Makhloufi, D Malbec, B Martha, T May, D Merrien, P Miailhes, C Miodovski, J-M Molina, P Morlat, E Mortier, D Neau, M Obadia, O Patey, J-L Pellegrin, V Perronne, P Philibert, G Pialoux, G Pichancourt, L Piroth, Y Poinsignon, I Poizot-Martin, T Prazuck, V Prendki, F Preveteau du Clary, D Quinsat, F Raffi, A Regnier, J Reynes, E Rosenthal, E Rouveix, D Salmon, F Salanville, J-L Schmitt, A Simon-Coutellier, A Sotto, F Souala, A Stein, F Timsit, P de Truchis, A Uludag, O Vaillant, R Verdon, A Verlesch-Langlin, J-P Viard, D Vittecoq, L Weiss, P Yéni, D Zucman, C Allavena, T Allegre, I Amri, B Autran, C Bacchus, C Blanc, S Bonne, B Bonnet, S Bouchez, C Charlier, P-H Consigny, C Duvivier, E Fourn, F Guiroy, T Huleux, C Katlama, C Lascoux-Combe, A Leplatois, T Lyavanc, J-M Molina, A Naqvi, G Nembot, Y Quertainmont, F Raffi, A Samri, L Schneider, S Seang, B C P Seksik, M Shoai-Tehrani, L Slama, M-A Valentin, Y Yazdanpanah, C Alloui, C Amiel, P André, E André-Garnier, G Anies, F Barin, P Bellecave, D Bettinger, M Bouvier-Alias, F Brun-Vézinet, A Calmy, V Calvez, W Caveng, A Chaillon, S Chapalay, C Charpentier, D Costagliola, J Cottalorda, C Delamare, C Delaugerre, J Dina, G Dos Santos, V Férré, P Flandre, H Fleury, S Fourati, C Gaille, G Giraudeau, A Guigon, S Haim-Boukobza, E Lagier, H Le Guillou-Guillemette, C Henquell, J Izopet, S Lambert-Niclot, M Leroux, A Maillard, I Malet, A-G Marcelin, S Marque-Juillet, B Masquelier, A Mirand, P Morand, B Montes, L Mouna, C Noel, C Pallier, G Peytavin, P Pinson-Recordon, J D Poveda, S Raymond, S Reigadas, A-M Roques, A de Rougemont, C Roussel, M-P Schmitt, V Schneider, E Schvoerer, A Signori-Schmuck, C Soulié, C Tamalet, J C Tardy, M-A Trabaud, A Vabret, S Vallet, S Yerly

Affiliations

¹ Laboratoire de Microbiologie, Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Necker-Enfants Malades, Paris, France EA7327, Université Paris Descartes, Sorbonne Paris Cité, Paris, France pierre.frange@nck.aphp.fr.
² Sorbonne Universités, UPMC Université Paris 06, UMR_S 1136, Institut Pierre Louis d'Epidémiologie et de Santé Publique, Paris, France.
³ Laboratoire de Virologie, AP-HP, Hôpital Bichat-Claude Bernard, Paris, France INSERM UMR1137 IAME, Université Paris Diderot, F-75018 Paris, France.
⁴ EA7327, Université Paris Descartes, Sorbonne Paris Cité, Paris, France Service de médecine interne, AP-HP, Hôpital Bicêtre, Le Kremlin Bicêtre, France.
⁵ Service de médecine interne, AP-HP, Hôpital Bicêtre, Le Kremlin Bicêtre, France INSERM CESP, U1018, Université Paris Sud, Faculté de Médecine Paris Sud, Le Kremlin Bicêtre, France.
⁶ INSERM CESP, U1018, Université Paris Sud, Faculté de Médecine Paris Sud, Le Kremlin Bicêtre, France Département d'Epidémiologie, AP-HP, Hôpital Bicêtre, Le Kremlin Bicêtre, France.
⁷ Laboratoire de Microbiologie, Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Necker-Enfants Malades, Paris, France.
⁸ Laboratoire de Microbiologie, Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Necker-Enfants Malades, Paris, France EA7327, Université Paris Descartes, Sorbonne Paris Cité, Paris, France.
⁹ Laboratoire de Virologie, Centre hospitalo-universitaire de Lille, Lille, France.
¹⁰ Laboratoire de Virologie, Hôpitaux Universitaires de Strasbourg, Strasbourg, France INSERM, U1109, LabEx TRANSPLANTEX Fédération de Médecine Translationnelle de Strasbourg, Université de Strasbourg, Strasbourg, France.
¹¹ Laboratoire de Microbiologie, Centre hospitalier régional d'Orléans, Orléans, France.
¹² Laboratoire de Virologie, AP-HP, Hôpital Saint Antoine, Sorbonne Universités, UPMC Univ Paris 06, UMR_S 1136, Institut Pierre Louis d'Epidémiologie et de Santé Publique, Paris, France.
¹³ Laboratoire de Virologie, Institut fédératif de biologie de Purpan, CHU de Toulouse, Hôpital Purpan, F-31300 Toulouse, France.
¹⁴ Laboratoire de Virologie et COREVIH Haute Normandie, Centre hospitalo-universitaire Charles Nicolle, Rouen, France.
¹⁵ Laboratoire de Virologie, Centre hospitalo-universitaire de Limoges, Limoges, France.
¹⁶ Laboratoire de Virologie, AP-HP, Groupe hospitalier Pitié-Salpêtrière, Sorbonne Universités, UPMC Univ Paris 06, UMR_S 1136, Institut Pierre Louis d'Epidémiologie et de Santé Publique, Paris, France.
¹⁷ Laboratoire de Virologie, AP-HP, Hôpital Saint Louis, INSERM U941, Université Paris Diderot, Laboratoire associé au Centre national de Référence du VIH, Paris, France.

PMID: 25885327
DOI: 10.1093/jac/dkv049

HIV-1 subtype B-infected MSM may have driven the spread of transmitted resistant strains in France in 2007-12: impact on susceptibility to first-line strategies

Pierre Frange et al. J Antimicrob Chemother. 2015 Jul.

. 2015 Jul;70(7):2084-9.

doi: 10.1093/jac/dkv049. Epub 2015 Feb 26.

Authors

Collaborators

S Abel, B Abraham, T Allegre, A Antoniotti, R Armero, B Audhuy, H Aumaitre, G Beaucaire, G Beck-Wirth, J L Berger, L Bernard, C Beuscart, L Bodard, O Bouchaud, F Boué, J-P Cabane, A Cabie, H Champagne, C Cheneau, J-M Chennebault, A Cheret, B Christian, A Compagnucci, V Daneluzzi, Y Debab, P Dellamonica, J-F Delfraissy, A Devidas, G Diab, J Doll, M C Drobacheff-Thebaut, A Durel, C Duvivier, J-L Esnault, L Faba, E Froguel, D Garipuy, V Garrait, L Geffray, C Genet, P Genet, L Gerard, J Ghosn, J-J Girard, P-M Girard, C Godin-Collet, P Hochedez, B Hoen, D Houlbert, C Jacomet, V Jeantils, K Jidar, C Katlama, E Klement, A Lafeuillade, C Lascoux, V Launay, A Lepretre, Y Levy, D Makhloufi, D Malbec, B Martha, T May, D Merrien, P Miailhes, C Miodovski, J-M Molina, P Morlat, E Mortier, D Neau, M Obadia, O Patey, J-L Pellegrin, V Perronne, P Philibert, G Pialoux, G Pichancourt, L Piroth, Y Poinsignon, I Poizot-Martin, T Prazuck, V Prendki, F Preveteau du Clary, D Quinsat, F Raffi, A Regnier, J Reynes, E Rosenthal, E Rouveix, D Salmon, F Salanville, J-L Schmitt, A Simon-Coutellier, A Sotto, F Souala, A Stein, F Timsit, P de Truchis, A Uludag, O Vaillant, R Verdon, A Verlesch-Langlin, J-P Viard, D Vittecoq, L Weiss, P Yéni, D Zucman, C Allavena, T Allegre, I Amri, B Autran, C Bacchus, C Blanc, S Bonne, B Bonnet, S Bouchez, C Charlier, P-H Consigny, C Duvivier, E Fourn, F Guiroy, T Huleux, C Katlama, C Lascoux-Combe, A Leplatois, T Lyavanc, J-M Molina, A Naqvi, G Nembot, Y Quertainmont, F Raffi, A Samri, L Schneider, S Seang, B C P Seksik, M Shoai-Tehrani, L Slama, M-A Valentin, Y Yazdanpanah, C Alloui, C Amiel, P André, E André-Garnier, G Anies, F Barin, P Bellecave, D Bettinger, M Bouvier-Alias, F Brun-Vézinet, A Calmy, V Calvez, W Caveng, A Chaillon, S Chapalay, C Charpentier, D Costagliola, J Cottalorda, C Delamare, C Delaugerre, J Dina, G Dos Santos, V Férré, P Flandre, H Fleury, S Fourati, C Gaille, G Giraudeau, A Guigon, S Haim-Boukobza, E Lagier, H Le Guillou-Guillemette, C Henquell, J Izopet, S Lambert-Niclot, M Leroux, A Maillard, I Malet, A-G Marcelin, S Marque-Juillet, B Masquelier, A Mirand, P Morand, B Montes, L Mouna, C Noel, C Pallier, G Peytavin, P Pinson-Recordon, J D Poveda, S Raymond, S Reigadas, A-M Roques, A de Rougemont, C Roussel, M-P Schmitt, V Schneider, E Schvoerer, A Signori-Schmuck, C Soulié, C Tamalet, J C Tardy, M-A Trabaud, A Vabret, S Vallet, S Yerly

Affiliations

¹ Laboratoire de Microbiologie, Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Necker-Enfants Malades, Paris, France EA7327, Université Paris Descartes, Sorbonne Paris Cité, Paris, France pierre.frange@nck.aphp.fr.
² Sorbonne Universités, UPMC Université Paris 06, UMR_S 1136, Institut Pierre Louis d'Epidémiologie et de Santé Publique, Paris, France.
³ Laboratoire de Virologie, AP-HP, Hôpital Bichat-Claude Bernard, Paris, France INSERM UMR1137 IAME, Université Paris Diderot, F-75018 Paris, France.
⁴ EA7327, Université Paris Descartes, Sorbonne Paris Cité, Paris, France Service de médecine interne, AP-HP, Hôpital Bicêtre, Le Kremlin Bicêtre, France.
⁵ Service de médecine interne, AP-HP, Hôpital Bicêtre, Le Kremlin Bicêtre, France INSERM CESP, U1018, Université Paris Sud, Faculté de Médecine Paris Sud, Le Kremlin Bicêtre, France.
⁶ INSERM CESP, U1018, Université Paris Sud, Faculté de Médecine Paris Sud, Le Kremlin Bicêtre, France Département d'Epidémiologie, AP-HP, Hôpital Bicêtre, Le Kremlin Bicêtre, France.
⁷ Laboratoire de Microbiologie, Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Necker-Enfants Malades, Paris, France.
⁸ Laboratoire de Microbiologie, Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Necker-Enfants Malades, Paris, France EA7327, Université Paris Descartes, Sorbonne Paris Cité, Paris, France.
⁹ Laboratoire de Virologie, Centre hospitalo-universitaire de Lille, Lille, France.
¹⁰ Laboratoire de Virologie, Hôpitaux Universitaires de Strasbourg, Strasbourg, France INSERM, U1109, LabEx TRANSPLANTEX Fédération de Médecine Translationnelle de Strasbourg, Université de Strasbourg, Strasbourg, France.
¹¹ Laboratoire de Microbiologie, Centre hospitalier régional d'Orléans, Orléans, France.
¹² Laboratoire de Virologie, AP-HP, Hôpital Saint Antoine, Sorbonne Universités, UPMC Univ Paris 06, UMR_S 1136, Institut Pierre Louis d'Epidémiologie et de Santé Publique, Paris, France.
¹³ Laboratoire de Virologie, Institut fédératif de biologie de Purpan, CHU de Toulouse, Hôpital Purpan, F-31300 Toulouse, France.
¹⁴ Laboratoire de Virologie et COREVIH Haute Normandie, Centre hospitalo-universitaire Charles Nicolle, Rouen, France.
¹⁵ Laboratoire de Virologie, Centre hospitalo-universitaire de Limoges, Limoges, France.
¹⁶ Laboratoire de Virologie, AP-HP, Groupe hospitalier Pitié-Salpêtrière, Sorbonne Universités, UPMC Univ Paris 06, UMR_S 1136, Institut Pierre Louis d'Epidémiologie et de Santé Publique, Paris, France.
¹⁷ Laboratoire de Virologie, AP-HP, Hôpital Saint Louis, INSERM U941, Université Paris Diderot, Laboratoire associé au Centre national de Référence du VIH, Paris, France.

PMID: 25885327
DOI: 10.1093/jac/dkv049

Abstract

Background: Our study describes the prevalence of transmitted drug resistance (TDR) among 1318 French patients diagnosed at the time of primary HIV-1 infection (PHI) in 2007-12.

Methods: HIV-1 resistance-associated mutations (RAMs) were characterized using both the 2009 WHO list of mutations and the French ANRS algorithm. A genotypic susceptibility score was estimated for each first-line recommended ART combination.

Results: Patients were mainly MSM (72.6%). Non-B variants were identified in 33.7% of patients. The proportion of TDR was estimated as 11.7% (95% CI 10.0-13.5). The prevalences of PI-, NRTI-, first-generation NNRTI and etravirine/rilpivirine-associated RAMs were 2.5%, 5.2%, 3.9% and 3.2%, respectively. Single, dual and triple class resistance was found in 9.6%, 1.0% and 1.1% of cases, respectively. Additionally, 5/331 strains isolated in 2010-12 had integrase inhibitor (II)-related RAMs (isolated E157Q mutation in all cases). TDR was more common among MSM than in other groups (12.9% versus 8.6%, P = 0.034), and in case of B versus non-B subtype infections (13.6% versus 7.9%, P = 0.002). The proportions of fully active combinations were ≥99.2%, ≥97.3% and ≥95.3% in cases of PI-, II- and NNRTI-based regimens, respectively. In 2010-12, the proportion of fully active efavirenz-based ART was lower in cases of subtype B versus non-B infection (P = 0.021).

Conclusions: Compared with our previous studies, the proportion of NRTI- and first-generation NNRTI-related TDR has continued to decline in French seroconverters. However, subtype B-infected MSM could drive the spread of resistant HIV strains. Finally, we suggest preferring PI- or II- to NNRTI-based combinations to treat PHI patients.

Keywords: HIV-1; primary HIV infection; resistance-associated mutations.

© The Author 2015. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

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HIV-1 subtype B-infected MSM may have driven the spread of transmitted resistant strains in France in 2007-12: impact on susceptibility to first-line strategies

Collaborators

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HIV-1 subtype B-infected MSM may have driven the spread of transmitted resistant strains in France in 2007-12: impact on susceptibility to first-line strategies

Authors

Collaborators

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Abstract

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Substances

LinkOut - more resources

Full Text Sources

Medical

Research Materials

Miscellaneous