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. 2015 Feb 25:15:83.
doi: 10.1186/s12885-015-1071-x.

The prognostic significance of age in operated and non-operated colorectal cancer

Jing Li  1   2 , Zhu Wang  3 , Xin Yuan  4 , Lichun Xu  5 , Jiandong Tong  6
Affiliations

The prognostic significance of age in operated and non-operated colorectal cancer

Jing Li et al. BMC Cancer. .

Abstract

Background: The prognostic significance of age in colorectal cancer remains controversial. Our purpose was to determine the impact of age at diagnosis on cause- specific survival and overall survival in patients with colorectal cancer.

Methods: Using Surveillance, Epidemiology, and End Results (SEER) population-based data, we identified 226,430 patients with colorectal cancer diagnosed between 1996 and 2005. Patients were separated into 10-year age groups. Five-year cancer cause-specific survival and overall survival data were obtained. Kaplan-Meier methods were adopted and multivariable Cox regression models were built for the analysis of long-term survival outcomes and risk factors.

Results: In the operated group, those aged 51-60 had the best prognosis with 5-year cause-specific survival of 72.3% and 5-year overall survival of 68.3%.In the non-operated group, those of young age 15-30 had the best prognosis with 5-year cause-specific survival of 21.2% and 5-year overall survival of 18.2%, and there was continued worsening in cause-specific survival and overall survival with increasing age, except for a small increase in the 51-60 age group (P < 0.001). Multivariable analysis demonstrated a statistically significant disadvantage in cause-specific survival in patients older than 60 (P < 0.001), but the difference between the 51-60 age group and the younger age group (15-30, 31-40, 41-50) wasn't statistically significant (P > 0.05) in both operated and non-operated patients.

Conclusions: There was no apparent difference in survival in colorectal cancer patients 60 and younger, but in those older than 60 years, there was worsening in overall survival and cause-specific survival in both operated and non-operated patients.

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Figures

Figure 1
Figure 1
Survival curves according to each age subgroups in colorectal patients in operated group.
Figure 2
Figure 2
Survival curves according to each age subgroups in colorectal patients in non-operated group.
Figure 3
Figure 3
Estimates of hazard ratios (HRs) of colorectal cancer-specific mortality changing with age for (a) operated and (b) non-operated group using quintic polynomial regression. The solid blue lines represent the estimates of HRs, whereas the dotted orange lines represent the 95% confidence intervals. All R2 values are reported.
See this image and copyright information in PMC

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