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Review
. 2014 Jan-Apr;8(1):9-12.
doi: 10.4103/0259-1162.128894.

Improved prophylaxis of postoperative nausea vomiting: Palonosetron a novel antiemetic

Akshaya N Shetti  1 , Dewan Roshan Singh  2 , Kusha Nag  2 , Rachita A Shetti  3 , V R Hemanth Kumar  2
Affiliations
Review

Improved prophylaxis of postoperative nausea vomiting: Palonosetron a novel antiemetic

Akshaya N Shetti et al. Anesth Essays Res. 2014 Jan-Apr.

Abstract

Many anti-emetics are used in clinical practice. Palonosetron hydrochloride is one of them. It is a novel, centrally acting antiemetic, and anti-nausea agent. This drug is an antagonist of serotonin receptor subtype 3 (5-HT3). This drug has longer duration of action which makes it useful in the prevention and treatment of acute and delayed onset of nausea and vomiting. This drug was initially used for chemotherapy induced nausea and vomiting. Federal drug agency (FDA) has approved it for prevention and treatment of post-operative nausea and vomiting. The literature search for this article was done using Google scholar and Pubmed using the terms "Palonosetron," "longer duration of action," "nausea," "vomiting," and "postoperative".

Keywords: 5-HT3; Antiemetics; anesthesia; nausea; palonosetron; post-operative; vomiting.

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Conflict of interest statement

Conflict of Interest: None declared.

Figures

Figure 1
Figure 1
Vomiting reflex and site of action of various drugs
Figure 2
Figure 2
Structure of Palonosetron
See this image and copyright information in PMC

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