Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2014 May-Aug;8(2):197-201.
doi: 10.4103/0259-1162.134503.

Palonosetron, Ondansetron, and Granisetron for antiemetic prophylaxis of postoperative nausea and vomiting - A comparative evaluation

Kumkum Gupta  1 , Ivesh Singh  1 , Prashant K Gupta  2 , Himanshu Chauhan  1 , Manish Jain  1 , Bhawna Rastogi  1
Affiliations

Palonosetron, Ondansetron, and Granisetron for antiemetic prophylaxis of postoperative nausea and vomiting - A comparative evaluation

Kumkum Gupta et al. Anesth Essays Res. 2014 May-Aug.

Abstract

Background: Postoperative nausea and vomiting is commonly associated with adverse consequences and hamper the postoperative recovery in spite of the availability of many antiemetic drugs and regimens for its prevention. The study was aimed to compare the prophylactic effects of intravenously administered palonosetron, ondansetron, and granisetron on prevention of postoperative nausea and vomiting after general anesthesia.

Materials and methods: This prospective, double-blind study, comprised 120 adult consented patients of ASA grade I and II of either gender, was carried out after approval of Institutional Ethical Committee. Patients were randomized into three equal groups of 40 patients each in double-blind manner. Group P received inj. palonosetron (0.075 mg), group O received inj. ondansetron (4 mg), and group G received inj. granisetron (2 mg) intravenously five minutes before induction of anesthesia. The need for rescue antiemetic, episode of postoperative nausea and vomiting, and side effects were observed for 12 hours in the post-anesthesia care unit. At the end of study, results were compiled and statistical analysis was done by using ANOVA, Chi-square test, and Kruskal Wallis Test. Value of P < 0.05 was considered significant.

Results: The incidence of nausea and vomiting was maximal during the first four hours postoperatively. The complete control of postoperative nausea and vomiting for first 12 hours was achieved in 30% patients of ondansetron group, 55% patients of granisetron group, and 90% patients of palonosetron group. Safety profile was more with palonosetron.

Conclusion: Palonosetron was comparatively highly effective to prevent the PONV after anesthesia due to its prolonged duration of action than ondansetron and granisetron.

Keywords: Granisetron; ondansetron; palonosetron; postoperative nausea and vomiting.

PubMed Disclaimer

Conflict of interest statement

Conflict of Interest: None declared.

References

    1. Islam S, Jain PN. Postoperative nausea and vomiting (PONV): A review article. Indian J Anaesth. 2004;48:253–8.
    1. Gan TJ, Meyer T, Apfel CC, Chung F, Davis PJ, Eubanks S, et al. Consensus guidelines for managing postoperative nausea and vomiting. Anesth Analg. 2003;97:62–71. - PubMed
    1. Loewen PS, Marra CA, Zed PJ. 5-HT3 receptor antagonist vs traditional agents for the prophylaxis of postoperative nausea and vomiting. Can J Anesth. 2000;47:1008–18. - PubMed
    1. Gan TJ. Selective serotonin 5-HT3 receptor antagonists for postoperative nausea and vomiting: Are they all the same? CNS Drugs. 2005;19:225–38. - PubMed
    1. Ho KY, Gan TJ. Pharmacology, pharmacogenetics, and clinical efficacy of 5-hydroxytryptamine type 3 receptor antagonists for postoperative nausea and vomiting. Curr Opin Anaesthesiol. 2006;19:606–11. - PubMed

LinkOut - more resources