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. 2015 Jan-Apr;9(1):34-8.
doi: 10.4103/0259-1162.150153.

Comparative analgesic efficacy of different doses of dexamethasone during infraumbilical surgery: A Randomized controlled trial

Ragi Jain  1 , C K Dua  1
Affiliations

Comparative analgesic efficacy of different doses of dexamethasone during infraumbilical surgery: A Randomized controlled trial

Ragi Jain et al. Anesth Essays Res. 2015 Jan-Apr.

Abstract

Background: Postoperative pain is a common complaint and despite the availability of various drugs, is still not managed well. Analgesic effects of glucocorticoids are still to be substantially established. Hence, we designed randomized, double-blind, placebo-controlled trial to compare the effect of two different doses of dexamethasone on postoperative pain in patients undergoing infra-umbilical surgeries under spinal anesthesia.

Methods: Ninety American Society of Anesthesiologists Grade I and II patients were randomized to receive injection dexamethasone 8 mg (Group DI), dexamethasone 16 mg (Group DII) or placebo (Group C) prior to performance of intrathecal block. Outcome studied was postoperative pain on the rest and motion and nausea and vomiting.

Result: There was no difference in Visual Analog Scale (VAS) scores during rest in all the three groups. However, VAS scores on motion showed a significant decrease in Group DII at 24 and 36 h when compared to Group C (95% confidence interval [CI] of mean at 24 h for Group C = 5.6093-7.1049 and Group DII = 4.8709-5.9567, P = 0.04; 95% CI of mean at 36 h for Group C = 4.5868-5.8418 and Group DII = 3.5388-4.7378, P = 0.01). There was no significant difference in the incidence of postoperative nausea and vomiting or additional analgesic requirements.

Conclusion: Dexamethasone 16 mg reduces postoperative pain on motion at 24 and 36 h. It has no effect on postoperative pain at rest or on nausea and vomiting.

Keywords: Dexamethasone; nausea and vomiting; postoperative pain; spinal anesthesia.

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Conflict of interest statement

Conflict of Interest: None declared.

Figures

Figure 1
Figure 1
Postoperative Visual Analog Scale (VAS) scores at rest. There is no significant difference in VAS scores between the three groups
See this image and copyright information in PMC

References

    1. Pöpping DM, Zahn PK, Van Aken HK, Dasch B, Boche R, Pogatzki-Zahn EM. Effectiveness and safety of postoperative pain management: A survey of 18 925 consecutive patients between 1998 and 2006 (2nd revision): A database analysis of prospectively raised data. Br J Anaesth. 2008;101:832–40. - PubMed
    1. Salerno A, Hermann R. Efficacy and safety of steroid use for postoperative pain relief. Update and review of the medical literature. J Bone Joint Surg Am. 2006;88:1361–72. - PubMed
    1. Filos KS, Lehmann KA. Current concepts and practice in postoperative pain management: Need for a change? Eur Surg Res. 1999;31:97–107. - PubMed
    1. Shang AB, Gan TJ. Optimising postoperative pain management in the ambulatory patient. Drugs. 2003;63:855–67. - PubMed
    1. Warfield CA, Kahn CH. Acute pain management. Programs in U.S. hospitals and experiences and attitudes among U.S. adults. Anesthesiology. 1995;83:1090–4. - PubMed