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. 2015 Apr 17;10(4):e0124506.
doi: 10.1371/journal.pone.0124506. eCollection 2015.

The epidemiology of chronic kidney disease in Northern Tanzania: a population-based survey

John W Stanifer  1 , Venance Maro  2 , Joseph Egger  3 , Francis Karia  2 , Nathan Thielman  1 , Elizabeth L Turner  4 , Dionis Shimbi  2 , Humphrey Kilaweh  2 , Oliver Matemu  2 , Uptal D Patel  5
Affiliations

The epidemiology of chronic kidney disease in Northern Tanzania: a population-based survey

John W Stanifer et al. PLoS One. .

Abstract

Background: In sub-Saharan Africa, kidney failure has a high morbidity and mortality. Despite this, population-based estimates of prevalence, potential etiologies, and awareness are not available.

Methods: Between January and June 2014, we conducted a household survey of randomly-selected adults in Northern Tanzania. To estimate prevalence we screened for CKD, which was defined as an estimated glomerular filtration rate ≤ 60 ml/min/1.73m2 and/or persistent albuminuria. We also screened for human immunodeficiency virus (HIV), diabetes, hypertension, obesity, and lifestyle practices including alcohol, tobacco, and traditional medicine use. Awareness was defined as a self-reported disease history and subsequently testing positive. We used population-based age- and gender-weights in estimating prevalence, and we used generalized linear models to explore potential risk factors associated with CKD, including living in an urban environment.

Results: We enrolled 481 adults from 346 households with a median age of 45 years. The community-based prevalence of CKD was 7.0% (95% CI 3.8-12.3), and awareness was low at 10.5% (4.7-22.0). The urban prevalence of CKD was 15.2% (9.6-23.3) while the rural prevalence was 2.0% (0.5-6.9). Half of the cases of CKD (49.1%) were not associated with any of the measured risk factors of hypertension, diabetes, or HIV. Living in an urban environment had the strongest crude (5.40; 95% CI 2.05-14.2) and adjusted prevalence risk ratio (4.80; 1.70-13.6) for CKD, and the majority (79%) of this increased risk was not explained by demographics, traditional medicine use, socioeconomic status, or co-morbid non-communicable diseases (NCDs).

Conclusions: We observed a high burden of CKD in Northern Tanzania that was associated with low awareness. Although demographic, lifestyle practices including traditional medicine use, socioeconomic factors, and NCDs accounted for some of the excess CKD risk observed with urban residence, much of the increased urban prevalence remained unexplained and will further study as demographic shifts reshape sub-Saharan Africa.

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Conflict of interest statement

Competing Interests: The authors have declared that no competing interests exist.

Figures

Fig 1
Fig 1. Study Setting.
Map showing the sampling area of Moshi Urban and Moshi Rural in the Kilimanjaro Region of Northern Tanzania.
Fig 2
Fig 2. Venn diagram.
The proportion of CKD associated with HIV, hypertension, and diabetes.
Fig 3
Fig 3. Forest plot.
The crude and fully-adjusted (model 4) prevalence risk ratios for CKD by each variable relative to the reference group for each variable.
See this image and copyright information in PMC

References

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