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. 2015 Jul;33(7):371-3.
doi: 10.1016/j.tibtech.2015.03.011. Epub 2015 Apr 14.

Cobalamin-dependent enzymatic O-, N-, and S-demethylation

Nina Richter  1 , Ferdinand Zepeck  2 , Wolfgang Kroutil  3
Affiliations

Cobalamin-dependent enzymatic O-, N-, and S-demethylation

Nina Richter et al. Trends Biotechnol. 2015 Jul.

Abstract

Cobalamine cofactors (vitamin B12) are complex organometallic molecules that are crucial for the activity of a variety of different interesting enzymes such as isomerases, methyltransferases, and dehalogenases. Developments in understanding the structure, mechanism, and role in nature of methylcobalamin-dependent methyltransferases make them excellent candidates for biotechnological applications such as biocatalytic dealkylation.

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