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Meta-Analysis
. 2015 Feb 11:15:9.
doi: 10.1186/s12877-015-0007-2.

A meta-analysis of prospective studies on the role of physical activity and the prevention of Alzheimer's disease in older adults

Michael W Beckett  1 , Christopher I Ardern  2 , Michael A Rotondi  3
Affiliations
Meta-Analysis

A meta-analysis of prospective studies on the role of physical activity and the prevention of Alzheimer's disease in older adults

Michael W Beckett et al. BMC Geriatr. .

Abstract

Background: The incidence of Alzheimer's disease is increasing as the global population ages. Given the limited success of pharmaceuticals in preventing this disease, a greater emphasis on non-pharmaceutical approaches is needed. The aim of this study was to quantify the association between Alzheimer's disease and physical activity in older adults over the age of 65 years.

Methods: A meta-analytic approach was used to determine if physical activity reduced the risk of Alzheimer's disease in individuals 65 years or older. Some evidence indicates that physical activity may improve cognitive function in older adults, while other evidence is inconclusive. The purpose of this study was to examine if prevention of Alzheimer's disease is possible if started at a later age. The precise brain changes that occur with the onset of Alzheimer's disease are not fully known, and therefore may still be influenced by preventative measures even in advancing age. Determining if physical activity can inhibit the onset of the disease at any age may motivate individuals to adopt an "it's never too late" mentality on preventing the onset of this debilitating disease. Longitudinal studies of participants who were 65 years or older at baseline were included. A total of 20,326 participants from nine studies were included in this analysis.

Results: The fixed effects risk ratio is estimated as 0.61 (95% CI 0.52-0.73) corresponding to a statistically significant overall reduction in risk of Alzheimer's disease in physically active older adults compared to their non-active counterparts.

Conclusion: Physical activity was associated with a reduced risk of Alzheimer's disease in adults over the age of 65 years. Given the limited treatment options, greater emphasis should be paid to primary prevention through physical activity amongst individuals at high-risk of Alzheimer's disease, such as those with strong genetic and family history.

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Figures

Figure 1
Figure 1
Caption: PRISMA flowchart of review search.
Figure 2
Figure 2
Caption: physical activity and the reduction of risk in developing Alzheimer’s disease.
See this image and copyright information in PMC

References

    1. World Health Organization . World Health Organization. 2012. Dementia: a public health priority.
    1. Thies W, Bleiler L. Alzheimer’s disease facts and figures. Alzheimers Dement. 2013;9:208–45. doi: 10.1016/j.jalz.2013.02.003. - DOI - PubMed
    1. Barnes D, Yaffe K, Byers A, McCormich M, Schaefer C, Whitmer R. Midlife vs late-life depressive symptoms and risk of dementia: differential effects for Alzheimer’s disease and vascular dementia. Arch Gen Psychiatry. 2012;69:493–8. doi: 10.1001/archgenpsychiatry.2011.1481. - DOI - PMC - PubMed
    1. Brookmeyer R, Johnson E, Ziegler-Graham K, Arrighi H. Forecasting the global burden of Alzheimer’s disease. Alzheimers Dement. 2007;3:186–91. doi: 10.1016/j.jalz.2007.04.381. - DOI - PubMed
    1. Erickson K, Weinstein A, Lopez O. Physical activity, brain plasticity, and Alzheimer’s disease. Arch Med Res. 2012;43:615–21. doi: 10.1016/j.arcmed.2012.09.008. - DOI - PMC - PubMed

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