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. 2015 Mar 13:13:105.
doi: 10.1186/s12957-015-0510-0.

Lymph node ratio is an independent prognostic factor for patients after resection of pancreatic cancer

Han-xiang Zhan  1 , Jian-wei Xu  2 , Lei Wang  3 , Guang-yong Zhang  4 , San-yuan Hu  5
Affiliations

Lymph node ratio is an independent prognostic factor for patients after resection of pancreatic cancer

Han-xiang Zhan et al. World J Surg Oncol. .

Abstract

Background: The prognostic value of lymph node ratio (LNR) in pancreatic cancer remains controversial. In the current retrospective study, we assessed the value of LNR on predicting the survival of postoperative patients with pancreatic cancer.

Methods: Medical records of patients who underwent pancreatic resection for pancreatic cancer in the department of general surgery, Qilu Hospital, Shandong University were reviewed retrospectively. Demographic, clinicopathological, tumor-specific data, and histopathological reports were collected. Univariate and multivariate survival analyses were performed.

Results: A total of 83 patients with pancreatic cancer were collected. The mean number of examined LN was 8.2 ± 6.1 (0 to 26). Differential degree (low) (P = 0.019, hazard ratio (HR) = 2.276, 95% confidence interval (CI): 1.171 to 4.424) and LNR >0.2 (P = 0.018, HR = 2.685, 95% CI: 1.253 to 5.756) were independent adverse prognostic factors according to the multivariate survival analysis.

Conclusions: Our study indicated that LNR >0.2 was an independent adverse prognostic factor for pancreatic cancer, which may provide important information for prognostic assessment.

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Figures

Figure 1
Figure 1
Kaplan-Meier survival curves. Left panel, survival analysis based on LNR. Right panel, survival analysis based on the total number of examined LN. LN, lymph node; LNR, lymph node ratio.
See this image and copyright information in PMC

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