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Review
. 2015 Mar 19:9:61.
doi: 10.1186/s13256-015-0533-8.

Breast cancer associated with neurofibromatosis type 1: a case series and review of the literature

Jihane Khalil  1 , Mohamed Afif  2 , Hanan Elkacemi  3 , Meryem Benoulaid  4 , Tayeb Kebdani  5 , Noureddine Benjaafar  6
Affiliations
Review

Breast cancer associated with neurofibromatosis type 1: a case series and review of the literature

Jihane Khalil et al. J Med Case Rep. .

Abstract

Introduction: Neurofibromatosis type 1, also known as Von Recklinghausen's disease, is a rare neuroectodermal disease that mainly affects the skin and the nervous system. Patients with neurofibromatosis type 1 have a higher risk of developing various types of cancers, especially tumors derived from the embryogenic neural crest. However, its association with breast cancer has seldom been reported.

Case presentation: We report the cases of three white Arabic women diagnosed with neurofibromatosis type 1, with a median age of 40-years-old (range: 39 to 43), who sought treatment at our centre for breast cancer.

Conclusions: The association between neurofibromatosis type 1 and breast cancer is uncommon. In our case series we readdress this association through a literature review.

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Figures

Figure 1
Figure 1
Case one: photograph of café-au-lait spots.
Figure 2
Figure 2
Case two: photograph of neurofibromas in the trunk and the limbs after mastectomy.
See this image and copyright information in PMC

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