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. 2015 Feb 27:8:57.
doi: 10.1186/s13104-015-1014-2.

Neurological outcomes in Chiari type II malformations and their correlation to morphological findings and fetal heart rate patterns: a retrospective study

Yuka Otera  1 , Seiichi Morokuma  2 , Kotaro Fukushima  3 , Ai Anami  4 , Yasuo Yumoto  5 , Yushi Ito  6 , Masayuki Ochiai  7 , Kimiaki Hashiguchi  8 , Norio Wake  9 , Haruhiko Sago  10 , Kiyoko Kato  11
Affiliations

Neurological outcomes in Chiari type II malformations and their correlation to morphological findings and fetal heart rate patterns: a retrospective study

Yuka Otera et al. BMC Res Notes. .

Abstract

Background: Correlations among Chiari type II malformation (CMII) morphological findings, the proportion of fetal heart rate patterns corresponding to the quiet phase (QP), and neurological outcomes have yet to be investigated.

Findings: The correlations among the morphological findings (i.e., the degree of ventriculomegaly, myelomeningocele levels, and degree of cerebellar herniation), proportion of time spent in QP, and developmental quotients (DQs) were analyzed in 22 children. The proportion of time spent in QP was compared between children with poor neurological outcomes (n = 9) and those with good outcomes (n = 13). Pearson's correlations and the Mann-Whitney U-test were used to assess for statistical significance; P < 0.05 was considered statistically significant. No significant differences were observed between the DQs and morphological findings, but the DQs and the proportion of time spent in QP were significantly correlated (r = 0.287, P = 0.01). The proportion of time spent in QP was significantly different between children with poor outcomes and those with good outcomes (median, 11% [range, 0-32%] vs. 28% [range, 2-55%]; P = 0.006).

Conclusions: The proportion of fetal heart rate patterns corresponding to the QP might be a useful predictor of neurological outcomes in 2-year-old children with CMII.

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Figures

Figure 1
Figure 1
Correlations between the developmental quotient (DQ) and atrial width (AW) of the lateral ventricle.
Figure 2
Figure 2
Correlation between the developmental quotient and the level of the myelomeningocele. 1, thoracic; 2, L1–2; 3, L3–4; 4, L5–S1; and 5, sacral.
Figure 3
Figure 3
Correlation between the developmental quotient (DQ) and the degree of the cerebellar herniation. 2, below the foramen magnum to the inferior margin of C2; 3, below C2 to the inferior margin of C3; and 4, below C3 to the inferior margin of ≥ C4.
Figure 4
Figure 4
Correlation between the developmental quotient (DQ) and the proportion of fetal heart rate patterns that correspond to the quiet phase (QP%).
Figure 5
Figure 5
Quiet phase proportions (QP%) between children with poor neurological outcomes and children with good outcomes. The solid line indicates the median value for each group.
See this image and copyright information in PMC

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