Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comparative Study
. 2015 Mar 5;44(1):11.
doi: 10.1186/s40463-015-0064-8.

Chronic rhinosinusitis: an under-researched epidemic

Luke Rudmik  1
Affiliations
Comparative Study

Chronic rhinosinusitis: an under-researched epidemic

Luke Rudmik. J Otolaryngol Head Neck Surg. .

Abstract

Background: Chronic rhinosinusitis (CRS) is a highly prevalent inflammatory disease with significant impacts on patient quality of life and daily productivity. Evaluating the volume of research on CRS, relative to similar chronic diseases, may provide insight into current disparities in research prioritization.

Methods: A systematic review was performed using Ovid MEDLINE (R) (1970 - December 31st, 2014) to define the volume of research publications for CRS, asthma, and diabetes mellitus (DM). Primary outcomes were overall volume of research publications and volume of publications per year. A subgroup analysis was performed using chi-square (χ2) omnibus test with 2×3 contingency tables to identify significant differences in the proportion of total randomized controlled trials, systematic reviews, meta-analyses, and economic evaluation publications between CRS, asthma, and DM groups.

Results: There were substantial disparities in the volume of research published over the last 45 years for CRS (n = 7,962), asthma (n = 136,652), and DM (n = 337,411). Although the volume of research for CRS in increasing, the disparities in the annual publication volumes between CRS, asthma, and DM appeared consistent over the last 45 years.

Conclusions: Outcomes from this review have demonstrated a large disparity in the volume of published research for CRS compared to asthma and DM. Given the similarities in prevalence rates, impact on quality of life and economic burden, the relative under supply of CRS research should prompt efforts to increase research prioritization for this chronic disease.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Publications per year. (A) DM vs. Asthma vs. CRS; (B) Asthma vs. CRS; (C) CRS alone.
See this image and copyright information in PMC

References

    1. Canadian Institutes of Health Research (CIHR). Mandate. http://www.cihr-irsc.gc.ca/e/7263.html. Accessed Jan.2, 2015.
    1. National Institutes of Health (NIH). Mission Statement. http://www.nih.gov/about/mission.htm. Accessed Jan.2, 2015.
    1. National Institute for Clinical Excellence (NICE). http://www.nice.org.uk/about/what-we-do. Accessed Jan.2, 2015.
    1. Fleurence RL. Setting priorities for research: a practical application of ‘payback’ and expected value of information. Health Econ. 2007;16(12):1345–57. doi: 10.1002/hec.1225. - DOI - PubMed
    1. Fleurence RL, Torgerson DJ. Setting priorities for research. Health Policy. 2004;69(1):1–10. doi: 10.1016/j.healthpol.2003.11.002. - DOI - PubMed

MeSH terms