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Clinical Trial
. 2015 May;115(2):253-6.
doi: 10.1016/j.radonc.2015.03.017. Epub 2015 Apr 15.

Double blind randomized prospective trial of bethanechol in the prevention of radiation-induced salivary gland dysfunction in head and neck cancer patients

Graziella Chagas Jaguar  1 , Eduardo Nóbrega Pereira Lima  2 , Luiz Paulo Kowalski  3 , Antônio Cássio Pellizzon  4 , André Lopes Carvalho  5 , Karina Waiswol Boccaletti  4 , Fabio Abreu Alves  6
Affiliations
Clinical Trial

Double blind randomized prospective trial of bethanechol in the prevention of radiation-induced salivary gland dysfunction in head and neck cancer patients

Graziella Chagas Jaguar et al. Radiother Oncol. 2015 May.

Abstract

This study assessed the prophylactic bethanechol use to prevent salivary gland dysfunction during radiotherapy. A total of 97 head and neck cancer patients were allocated into two groups: Bethanechol or Placebo. Bethanechol group presented significantly improve of salivary parameters. Bethanechol was effective in decreasing the salivary gland damage.

Keywords: Bethanechol; Intensity modulated radiation therapy; Salivary flow; Salivary glands scintigraphy; Three-dimensional radiotherapy; Xerostomia.

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